Prediction of Alzheimer’s disease biomarker status defined by the ‘ATN framework’ among cognitively healthy individuals: results from the EPAD longitudinal cohort study

Calvin, Catherine M.; de Boer, Casper; Raymont, Vanessa; Gallacher, John; Koychev, Ivan

doi:10.1186/s13195-020-00711-5

Alzheimer's Research & Therapy

Table 2 ATN group differences by risk factor

From: Prediction of Alzheimer’s disease biomarker status defined by the ‘ATN framework’ among cognitively healthy individuals: results from the EPAD longitudinal cohort study

		Normal AD biomarkers	Alzheimer’s pathologic change	Alzheimer’s disease	Alzheimer’s and non-AD pathologic change	Non-AD pathology
Bonferroni test for subgroup comparisons
Risk factors (continuous)		P value	P value	P value	P value
Age	Alzheimer’s pathologic change	1.0
	Alzheimer’s disease	< 0.001	< 0.001
	AD/non-AD pathologic change	1.0	0.82	< 0.001
	Non-AD pathology	< 0.001	0.07	0.15	0.02	–
WML volume*	Alzheimer’s pathologic change	0.02
	Alzheimer’s disease	< 0.001	0.14
	AD/non-AD pathologic change	0.10	1.0	1.0
	Non-AD pathology	1.0	0.72	0.003	0.33	–
Framingham CVD	Alzheimer’s pathologic change	1.0
	Alzheimer’s disease	0.02	0.03
	AD /non-AD pathologic change	1.0	1.0	0.07
	Non-AD pathology	0.08	0.18	1.0	0.30	–
Framingham stroke	Alzheimer’s pathologic change	1.0
	Alzheimer’s disease	< 0.001	0.01
	AD/non-AD pathologic change	1.0	1.0	0.13
	Non-AD pathology	< 0.001	0.06	1.0	0.49	–
MMSE	Alzheimer’s pathologic change	1.0
	Alzheimer’s disease	0.005	0.003
	AD/non-AD pathologic change	1.0	1.0	0.08
	Non-AD pathology	1.0	0.73	0.35	1.0	–
Verbal learning	Alzheimer’s pathologic change	1.0
	Alzheimer’s disease	0.02	0.08
	AD/non-AD pathologic change	1.0	1.0	0.13
	Non-AD pathology	1.0	1.0	1.0	1.0	–
Coding	Alzheimer’s pathologic change	1.0
	Alzheimer’s disease	< 0.001	0.09
	AD/non-AD pathologic change	1.0	1.0	0.09
	Non-AD pathology	0.12	1.0	0.84	1.0	–
Chi-square residuals test for evaluating subgroup contribution to group differences
Risk factors (binary)		Adjusted R	Adjusted R	Adjusted R	Adjusted R	Adjusted R
APOE4		− 4.74	3.18	5.45	− 0.10	− 0.65
Family history		− 0.22	0.25	3.28	− 0.87	− 1.92

P values in bold survive Bonferroni correction (0.5/56 = 0.009). Adjusted standardised residuals (R) in bold represent significant subgroup effects, i.e. R > 2 indicates that the number of cases with a risk factor within the ATN subgroup is significantly larger than expected if the null hypothesis is true (p < 0.05); R < −2 indicates that the numbers of cases with a risk factor within the ATN subgroup is significantly smaller than expected if the null hypothesis is true

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ISSN: 1758-9193

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