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Table 1 Baseline demographic characteristics of 272 participants who completed the baseline study

From: Effect of APOE ε4 genotype on amyloid-β and tau accumulation in Alzheimer’s disease

  Aβ± Aβ− Aβ+
ε4− ε4+ ε4− ε4+ ε4− ε4+
N 195 77 134 24 61 53
Baseline age (years) 70.4 ± 10.3 70.0 ± 8.6 68.4 ± 10.3 65.5 ± 8.3 74.7 ± 8.7 72.1 ± 7.9
Females (%) 127 (65%) 51 (66%) 90 (67%) 16 (67%) 37 (61%) 35 (66%)
Education (years) 11.1 ± 4.9 11.2 ± 5.0 11.0 ± 4.9 11.4 ± 4.2 11.2 ± 4.8 11.1 ± 5.3
Duration (years) 2.6 ± 1.5 3.1 ± 1.4 2.3 ± 1.5 2.4 ± 1.3 3.0 ± 1.5 3.2 ± 1.4
Aβ-positivity (%) 61 (31%) 53 (69%)a 0 (0%) 0 (0%) 61 (100%) 53 (100%)
ε2/2:ε2/3:ε3/3 1:37:157 n.a. 1:31:102 n.a. 0:6:55 n.a.
ε2/4:ε3/4:ε4/4 n.a. 2:60:15 n.a. 2:21:1 n.a. 0:39:14
Baseline diagnosis, CU/MCI/DEM (%) 79/75/41 (41/38/21%) 17/30/30a (22/39/39%) 72/49/13 (54/37/10%) 15/7/2 (63/29/8%) 7/26/28 (11/43/46%) 2/23/28 (4/43/53%)
MMSE 25.4 ± 4.7 23.5 ± 5.3a 26.8 ± 3.2 26.7 ± 2.5 22.2 ± 5.7 22.1 ± 5.7
CDR-SB 1.6 ± 2.3 2.7 ± 2.5a 0.9 ± 1.5 0.8 ± 1.4 3.1 ± 3.0 3.6 ± 2.4
  1. Data are presented as mean ± SD
  2. Abbreviations: CU cognitively unimpaired, MCI mild cognitive impairment, DEM dementia, Aβ± Aβ-positivity, ApoE apolipoprotein E, MMSE Mini-Mental State Examination, CDR-SB Clinical Dementia Rating sum-of-boxes
  3. aP < 0.05 for the comparisons between the ε4− and ε4+