Fig. 2
From: α-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer’s disease
Levels of ADAM10 in AD CSF samples. a Schematic representation of the domains of transmembrane type I ADAM10 protein. b Western blots of CSF samples from controls (C), p.Tyr167* mutation carriers (mAD; cases I.1 and I.3), and sporadic AD (sAD) subjects using an ADAM10 antibody specific for the mid-region, common to all species. c Densitometric quantification of the 80-, 55-, and 50-kDa bands for the individual controls (n = 12; black circles) and AD cases (sAD, n = 10; white circles; mAD, n = 2; gray triangles). The data represent the means ± SEM in arbitrary units. For AD, means ± SEM represent values for sAD. *Significantly different (p < 0.007) from the control group, as assessed by Student’s t test (non-significant p = 0.17 value for the 80-kDa ADAM10 form)