Table 1 Description of the DELCODE sample at baseline
Total (n = 687) | CO (n = 209) | SCD (n = 242) | MCI (n = 115) | AD (n = 77) | REL (n = 44) | F value/χ2 value | |
|---|---|---|---|---|---|---|---|
Sex (female), n (%) | 351 (51.1) | 120 (57.4) | 117 (48.3) | 42 (36.5)** | 43 (55.8) | 29 (65.9) | 18.4, p = .001 |
Age, mean (SD) | 70.4 (5.9) | 68.8 (5.3) | 71.1 (5.7)*** | 72.1 (5.3)*** | 73.7 (6.7)*** | 64.6 (3.9)*** | 27.32 p < .001 |
Education years, mean (SD) | 14.4 (3.0) | 14.8 (2.8) | 14.8 (3.1) | 14.0 (3.0) | 13.2 (3.3)** | 14.1 (2.6) | 5.72, p < .001 |
MMSE score, mean (SD) | 28.4 (2.4) | 29.4 (0.9) | 29.2 (1.1) | 27.8 (1.8)*** | 23.5 (3.1)*** | 29.3 (1.1) | 251.02, p < .001 |
Expresses worry about memory (ECog), n (%) | 386 (58.7) | 27 (13.2) | 193 (83.2)*** | 93 (85.3)*** | 56 (80.0)*** | 17 (39.5)*** | 282.73, p < .001 |
MEM, mean (SD) | 4.02 × 10−7 (0.98) | 0.60 (0.39) | 0.34 (0.47)*** | −0.68 (0.67)*** | −1.99 (0.62)*** | 0.51 (0.61) | 446.38, p < .001 |
CSF biomarkers | n = 317 | n = 76 | n = 104 | n = 74 | n = 39 | n = 24 | |
Aß42 (pg/ml), mean (SD) | 677.7 (317.3) | 851.8 (301.6) | 715.5 (310.6)* | 568.4 (278.8)*** | 390.5 (137.2)*** | 767 (289.9) | 20.98, p < .001 |
Aß42 < 496 pg/ml (n, %) | 110 (34.7) | 10 (13.2) | 25 (24.0) | 39 (52.7)*** | 31 (79.5)*** | 5 (20.8) | 67.93, p < .001 |
t-tau (pg/ml), mean (SD) | 489.8 (265.5) | 389.9 (160.1) | 408.4 (192.2) | 556.2 (258.7)*** | 844.8 (338.8)*** | 372.8 (103.9) | 35.85, p < .001 |
t-tau > 470 pg/ml, n (%) | 127 (40.2) | 18 (24.0) | 31 (29.9) | 40 (54.1)*** | 34 (87.2)*** | 4 (16.7) | 60.11, p < .001 |
p-tau 181 (pg/ml), mean (SD) | 60.4 (30.3) | 51.3 (18.4) | 51.73 (23.9) | 67.4 (31.8)** | 96.1 (38.6)*** | 46.8 (12.3) | 24.87, p < .001 |
p-tau 181 > 57 pg/ml, n (%) | 135 (44.4) | 24 (31.6) | 30 (30.6) | 43 (61.4)** | 33 (86.8)*** | 5 (22.7) | 52.74, p < .001 |