From: Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia
SCD trajectory, stratified by agea | No. of MCI and dementia/total (%) | Hazard ratio (95% CI)c | p value | Survival (25th centile) in years (95% CI)b |
---|---|---|---|---|
Participants < 75 years | ||||
No SCD | 115/1980 (5.8) | 1.0 (Ref) | Ref | Not availabled |
Intermittent SCD | 36/473 (7.6) | 1.2 (0.8–1.8) | 0.350 | 8.5 (7.5–9.5) |
Persistent SCD | 43/362 (11.9) | 1.9 (1.2–2.9) | 0.003 | 6.9 (5.8–8.0) |
Participants ≥ 75 years | ||||
No SCD | 303/1934 (15.7) | 1.0 (Ref) | Ref | 6.2 (5.7–6.6) |
Intermittent SCD | 128/549 (23.3) | 1.4 (1.2–1.8) | 0.001 | 4.4 (3.8–5.0) |
Persistent SCD | 103/363 (28.4) | 2.2 (1.8–2.8) | < 0.001 | 3.2 (2.2–4.3) |