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Table 4 Risk of mild cognitive impairment and dementia across the different trajectories of subjective cognitive decline, further stratified by age (n = 5661)

From: Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia

SCD trajectory, stratified by agea No. of MCI and dementia/total (%) Hazard ratio (95% CI)c p value Survival (25th centile) in years (95% CI)b
Participants < 75 years
 No SCD 115/1980 (5.8) 1.0 (Ref) Ref Not availabled
 Intermittent SCD 36/473 (7.6) 1.2 (0.8–1.8) 0.350 8.5 (7.5–9.5)
 Persistent SCD 43/362 (11.9) 1.9 (1.2–2.9) 0.003 6.9 (5.8–8.0)
Participants ≥ 75 years
 No SCD 303/1934 (15.7) 1.0 (Ref) Ref 6.2 (5.7–6.6)
 Intermittent SCD 128/549 (23.3) 1.4 (1.2–1.8) 0.001 4.4 (3.8–5.0)
 Persistent SCD 103/363 (28.4) 2.2 (1.8–2.8) < 0.001 3.2 (2.2–4.3)
  1. SCD subjective cognitive decline, MCI mild cognitive impairment, CI confidence interval, Ref reference group
  2. aParticipants were stratified into 2 equal-sized age groups based on median age of 75 years
  3. bThe time needed for a quarter of the participants to develop MCI or dementia. The 95% CI was computed with 1000 bootstrap sampling
  4. cModel adjusted for baseline variables of age, sex, ethnicity, years of education, APOE e4 status, current smoking, diabetes mellitus, hypertension, hyperlipidemia, Mini-Mental State Examination score, total score on Geriatric Depression Scale, and presence of anxiety symptoms
  5. dNot available, because less than one-quarter of participants in this group developed MCI or dementia by the end of the follow-up period