From: Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia
SCD trajectory | No. of MCI and dementia / Total (%) | Model 1b | Model 2c | Model 3 (final)d | Survival (25th centile) in years (95% CI)a | |||
---|---|---|---|---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |||
No SCD | 418/3914 (10.7) | 1.0 (Ref) | Ref | 1.0 (Ref) | Ref | 1.0 (Ref) | Ref | 8.0 (7.5–8.5) |
Intermittent SCD | 164/1022 (16.0) | 1.5 (1.3–1.8) | < 0.001 | 1.5 (1.2–1.8) | < 0.001 | 1.4 (1.1–1.7) | 0.001 | 5.8 (5.3–6.4) |
Persistent SCD | 146/725 (20.1) | 2.5 (2.0–3.0) | < 0.001 | 2.4 (2.0–2.9) | < 0.001 | 2.2 (1.8–2.7) | < 0.001 | 4.7 (3.7–5.8) |