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Table 2 Risk of mild cognitive impairment and dementia across the different trajectories of subjective cognitive decline (n = 5661)

From: Trajectories of subjective cognitive decline, and the risk of mild cognitive impairment and dementia

SCD trajectory No. of MCI and dementia / Total (%) Model 1b Model 2c Model 3 (final)d Survival (25th centile) in years (95% CI)a
HR (95% CI) p value HR (95% CI) p value HR (95% CI) p value
No SCD 418/3914 (10.7) 1.0 (Ref) Ref 1.0 (Ref) Ref 1.0 (Ref) Ref 8.0 (7.5–8.5)
Intermittent SCD 164/1022 (16.0) 1.5 (1.3–1.8) < 0.001 1.5 (1.2–1.8) < 0.001 1.4 (1.1–1.7) 0.001 5.8 (5.3–6.4)
Persistent SCD 146/725 (20.1) 2.5 (2.0–3.0) < 0.001 2.4 (2.0–2.9) < 0.001 2.2 (1.8–2.7) < 0.001 4.7 (3.7–5.8)
  1. SCD subjective cognitive decline, No number, MCI mild cognitive impairment, CI confidence interval, HR hazard ratio, Ref reference group
  2. aThe time needed for a quarter of the participants to develop MCI or dementia. The 95% CI was computed with 1000 bootstrap sampling
  3. bCox regression included the SCD trajectories, as well as adjusted for covariates of age, sex, and ethnicity
  4. cCovariate adjustment as in model 1, with additional adjustment for years of education, APOE e4 status, current smoking, diabetes mellitus, hypertension, hyperlipidemia, and Mini-Mental State Examination score
  5. dCovariate adjustment as in model 2, with additional adjustment for total score on Geriatric Depression Scale and presence of anxiety symptoms