Cerebrospinal fluid A beta 1–40 peptides increase in Alzheimer’s disease and are highly correlated with phospho-tau in control individuals

Lehmann, Sylvain; Dumurgier, Julien; Ayrignac, Xavier; Marelli, Cecilia; Alcolea, Daniel; Ormaechea, Juan Fortea; Thouvenot, Eric; Delaby, Constance; Hirtz, Christophe; Vialaret, Jérôme; Ginestet, Nelly; Bouaziz-Amar, Elodie; Laplanche, Jean-Louis; Labauge, Pierre; Paquet, Claire; Lleo, Alberto; Gabelle, Audrey

doi:10.1186/s13195-020-00696-1

Alzheimer's Research & Therapy

Table 1 Demographical and cerebrospinal fluid (CSF) biomarkers’ characteristics of the six cohorts: Montpellier 1 (Mtp-1), Montpellier 2 (Mtp-2), Paris, SPIN-Barcelona, ADNI-MS, and ADNI-Elecsys

From: Cerebrospinal fluid A beta 1–40 peptides increase in Alzheimer’s disease and are highly correlated with phospho-tau in control individuals

Cohort/analyte	NAD		AD		P	Cohort/analyte	NAD		AD		P
Mtp-1	Mean	SD	Mean	SD	P	SPIN-Barcelona	Mean	SD	Mean	SD	P
Aß40	7035	2800	8579	3274	< 0.0001	Aß40	6799	3633	7985	2891	0.0128
Aß42	909	399	561	237	< 0.0001	Aß42	793	288	440	81	< 0.0001
Tau	343	279	739	267	< 0.0001	Tau	284	223	727	392	< 0.0001
p-Tau	42	16	96	36	< 0.0001	p-Tau	47	22	103	47	< 0.0001
Age	67.0	11.4	70.7	9.2	0.0015	Age	66.1	10.1	70.8	8.3	0.0004
MMSE	22.1	6.2	19.8	7.5	0.1392	MMSE	26.6	6.2	23.5	4.6	0.0097
Sex (%M)	53.6%	–	38.1%	–	0.0040*	Sex (%M)	57.4%	–	38.0%	–	0.0055*
ApoE (% E4)	NA					ApoE (% E4)	63.3%	–	49.4%	–	0.1910*
Cohort/analyte	NAD		AD		P	Cohort/analyte	ADNI(−)		ADNI(+)		P
Mtp-2	Mean	SD	Mean	SD	P	ADNI-MS	Mean	SD	Mean	SD	P
Aß40	12,720	6046	16,802	6473	< 0.0001	Aß40	7387	2517	8101	2167	0.0032
Aß42	821	369	700	334	0.0002	Aß42	1076	547	620	231	< 0.0001
Tau	321	248	655	302	< 0.0001	Tau	66	24	140	58	< 0.0001
p-Tau	42	18	89	37	< 0.0001	p-Tau	23	8	50	18	< 0.0001
Age	66.0	12.7	70.0	9.3	0.0001	Age	75.4	6.7	74.0	7.5	0.0430
MMSE	21.9	7.3	19.6	5.4	0.0031	MMSE	27.3	2.4	25.9	2.6	< 0.0001
Sex (%M)	51.4%	–	50.9%	–	0.9114*	Sex (%M)	61.0%	–	58.6%	–	0.6349*
ApoE (% E4)	ND					ApoE (% E4)	53.8%	–	89.3%	–	< 0.001*
Cohort/analyte	NAD		AD		P	Cohort/analyte	ADNI(−)		ADNI(+)		P
Paris	Mean	SD	Mean	SD	P	ADNI-Elecsys	Mean	SD	Mean	SD	P
Aß40	10,767	4468	13,149	5850	< 0.0001	Aß40	15,865	5265	19,417	5224	< 0.0001
Aß42	925	277	574	200	< 0.0001	Aß42	1039	610	673	269	< 0.0001
Tau	236	134	609	280	< 0.0001	Tau	241	68	433	148	< 0.0001
p-Tau	42	16	90	37	< 0.0001	p-Tau	21	6	45	18	< 0.0001
Age	65.2	9.4	70.7	8.1	< 0.0001	Age	72.9	7.3	72.8	6.3	0.9155
MMSE	23.0	5.2	21.8	5.8	0.0069	MMSE	27.1	2.4	25.4	3.6	< 0.0001
Sex (%M)	51.9%	–	38.5%	–	0.0008*	Sex (%M)	59.8%	–	49.7%	–	0.0816*
ApoE (% E4)	NA					ApoE (% E4)	49.7%	–	38.6%	–	0.1538*

Results are expressed as the mean ± standard deviation (SD). Abbreviation: MMSE Mini-Mental State Examination, AD Alzheimer’s disease, NAD non-Alzheimer’s disease, ADNI(−) cognitive patients with non-Alzheimer’s disease PLM profile, ADNI(+) cognitive patients with Alzheimer’s disease PLM profile, P significance level of the Student t test and *chi-squared test for the comparison of two proportions. Values of Aβ40, Aβ42, tau, and p-tau (181) are in picograms per milliliter

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ISSN: 1758-9193

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