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Table 4 Linear regression of log-transformed plasma S1P and serum inflammatory markers

From: Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer’s disease and vascular cognitive impairment

  IL-6*, β (95% CI) IL-8*, β (95% CI) TNF*, β (95% CI)
d16:1 S1P* − 0.07 (−0.40, 0.26) − 0.12 (−0.24, 0.01) − 0.06 (− 0.20, 0.09)
d18:1 S1P* 0.79 (0.32, 1.26) 0.10 (−0.07, 0.28) 0.28 (0.07, 0.49)
d18:1 to d16:1 ratio* 0.38 (0.08, 0.68) 0.14 (0.03, 0.25) 0.16 (0.03, 0.29)
  1. IL-6 interleukin-6, IL-8 interleukin-8, TNF tumor necrotic factor, S1P sphingosine-1-phosphate, β mean difference, CI confidence interval
  2. *Log-transformed
  3. Adjusted for age, hypertension, hyperlipidemia, diabetes, and cardiovascular disease. Interpretation: A 1% increase in C18:1 to C16:1 ratio will give rise to β% increase in cytokines (IL-6, IL-8, or TNF) serum levels