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Table 4 Linear regression of log-transformed plasma S1P and serum inflammatory markers

From: Immunomodulatory sphingosine-1-phosphates as plasma biomarkers of Alzheimer’s disease and vascular cognitive impairment

 

IL-6*, β (95% CI)†

IL-8*, β (95% CI)†

TNF*, β (95% CI)†

d16:1 S1P*

− 0.07 (−0.40, 0.26)

− 0.12 (−0.24, 0.01)

− 0.06 (− 0.20, 0.09)

d18:1 S1P*

0.79 (0.32, 1.26)

0.10 (−0.07, 0.28)

0.28 (0.07, 0.49)

d18:1 to d16:1 ratio*

0.38 (0.08, 0.68)

0.14 (0.03, 0.25)

0.16 (0.03, 0.29)

  1. IL-6 interleukin-6, IL-8 interleukin-8, TNF tumor necrotic factor, S1P sphingosine-1-phosphate, β mean difference, CI confidence interval
  2. *Log-transformed
  3. †Adjusted for age, hypertension, hyperlipidemia, diabetes, and cardiovascular disease. Interpretation: A 1% increase in C18:1 to C16:1 ratio will give rise to β% increase in cytokines (IL-6, IL-8, or TNF) serum levels
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Alzheimer's Research & Therapy

ISSN: 1758-9193