Table 2 Adjusted hazard ratio (aHR) of Alzheimer’s disease according to vascular risk factors

 Ranges (mg/dL)

< 200

200–239

≥ 240

–

–

 Total population, age- and sex-aHR

1 [reference]

1.013 (0.971–1.058)

1.085 (1.025–1.149)

–

–

 Total population, aHR^†

1 [reference]

1.035 (0.991–1.082)

1.089 (1.025–1.156)

–

–

 Male, aHR^†

1 [reference]

0.998 (0.924–1.079)

1.055 (0.929–1.198)

–

–

 Female, aHR^†

1 [reference]

1.055 (1.000–1.114)

1.102 (1.028–1.181)

–

–

 Ranges (mg/dL)

< 100

100–129

130–159

160–189

≥ 190

 Total population, age- and sex-aHR

1 [reference]

0.952 (0.908–0.997)

0.981 (0.932–1.034)

1.045 (0.973–1.122)

1.017 (0.906–1.142)

 Total population, aHR^‡

1 [reference]

1.006 (0.959–1.055)

1.046 (0.991–1.103)

1.116 (1.039–1.199)

1.085 (0.966–1.218)

 Male, aHR^‡

1 [reference]

0.957 (0.887–1.033)

0.963 (0.878–1.056)

1.073 (0.932–1.235)

1.123 (0.855–1.474)

 Female, aHR^‡

1 [reference]

1.044 (0.981–1.111)

1.096 (1.026–1.171)

1.150 (1.056–1.252)

1.095 (0.961–1.247)

 Ranges (mg/dL)

≥ 60

59–40

< 40

–

–

 Total population, age- and sex-aHR

1 [reference]

0.965 (0.924–1.008)

1.000 (0.940–1.062)

 Total population, aHR^§

1 [reference]

0.945 (0.904–0.988)

0.941 (0.882–1.004)

 Male, aHR^§

1 [reference]

0.953 (0.880–1.031)

0.978 (0.880–1.087)

–

–

 Female, aHR^§

1 [reference]

0.943 (0.894–0.995)

0.913 (0.840–0.991)

–

–

 Ranges (mg/dL)

< 150

150–199

200–499

–

–

 Total population, age- and sex-aHR

1 [reference]

1.031 (0.981–1.085)

1.101 (1.044–1.161)

–

–

 Total population, aHR^||

1 [reference]

1.030 (0.978–1.084)

1.094 (1.034–1.156)

–

 Male, aHR^||

1 [reference]

1.100 (1.003–1.205)

1.084 (0.978–1.201)

–

–

 Female, aHR^||

1 [reference]

1.002 (0.941–1.067)

1.100 (1.030–1.176)

–

 Ranges (mg/dL)

< 70

70–99

100–125

≥ 126

–

 Total population, age- and sex-aHR

1 [reference]

0.850 (0.671–1.078)

0.868 (0.684–1.102)

1.029 (0.807–1.311)

–

 Total population, aHR^#

1 [reference]

0.897 (0.707–1.138)

0.882 (0.695–1.120)

0.896 (0.702–1.143)

–

 Male, aHR^#

1 [reference]

0.839 (0.577–1.219)

0.825 (0.567–1.200)

0.907 (0.618–1.330)

–

 Female, aHR^#

1 [reference]

0.932 (0.685–1.268)

0.918 (0.674–1.250)

0.891 (0.650–1.222)

–

 Ranges (mmHg)

< 120

120–129

130–139

≥ 140

–

 Total population, age- and sex-aHR

1 [reference]

0.951 (0.898–1.007)

0.890 (0.844–0.938)

0.887 (0.840–0.936)

–

 Total population, aHR**

1 [reference]

0.925 (0.872–0.982)

0.854 (0.805–0.905)

0.827 (0.771–0.888)

–

 Male, aHR**

1 [reference]

0.839 (0.577–1.219)

0.825 (0.567–1.200)

0.907 (0.618–1.330)

–

 Female, aHR**

1 [reference]

0.884 (0.821–0.953)

0.830 (0.772–0.893)

0.800 (0.734–0.873)

–

 Ranges (mmHg)

< 80

80–89

≥ 90

–

–

 Total population, age- and sex-aHR

1 [reference]

0.988 (0.948–1.030)

0.984 (0.931–1.040)

–

–

 Total population, aHR^††

1 [reference]

1.041 (0.996–1.089)

1.110 (1.037–1.188)

–

–

 Male, aHR^††

1 [reference]

1.035 (0.960–1.116)

1.018 (0.904–1.147)

–

–

 Female, aHR^††

1 [reference]

1.046 (0.990–1.106)

1.158 (1.066–1.259)

–

–

 Ranges

< 18.5

18.5–24.9

25–29.9

30–34.9

≥ 35

 Total population, age- and sex-aHR

1 [reference]

1.000 (0.918–1.089)

0.958 (0.876–1.049)

0.967 (0.840–1.114)

1.397 (0.769–2.538)

 Total population, aHR^‡‡

1 [reference]

0.981 (0.899–1.069)

0.914 (0.832–1.003)

0.901 (0.780–1.040)

1.292 (0.710–2.349)

 Male, aHR^‡‡

1 [reference]

1.065 (0.902–1.233)

1.004 (0.854–1.181)

1.117 (0.818–1.525)

2.428 (0.602–9.792)

 Female, aHR^‡‡

1 [reference]

0.929 (0.834–1.034)

0.859 (0.765–0.964)

0.828 (0.702–0.978)

1.100 (0.567–2.135)