Fig. 4

Annual changes in SUVR and expression of two major PCs in 78 Aβ-positive individuals who completed follow-up tau PET. Annual changes adjusted by age, years of education, sex, presence of ApoE ε4 allele, and baseline global cortical SUVR values are presented for each quartile group of PC1 (a) and PC2 scores (b) obtained from baseline tau PET. The standard residuals for annual changes and those for the two PCs after adjusting for age, years of education, sex, presence of ApoE ε4 allele, and baseline global cortical SUVR values are plotted in c and d. Asterisks represent a significant difference in the SUVR values between the first and other quartile groups after correction for multiple comparisons. Error bars represent the standard error of estimated means. The colors of the circles represent individual clinical status (blue = CU, green = MCI, and red = AD). Pearson’s correlation lines (solid), 95% confidence interval lines (dotted), correlation coefficients (R), and P values are presented within each plot. PC, principal component; Qn, quartiles