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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Differential diagnostic value of total alpha-synuclein assay in the cerebrospinal fluid between Alzheimer’s disease and dementia with Lewy bodies from the prodromal stage

Fig. 2

Total alpha-synuclein assay discriminates between AD and DLB (a) and b scatterplots of CSF alpha-synuclein. a CSF concentrations of total alpha-synuclein in each patient group (the number of patients per group was as follows: CS n = 21, pro-DLB n = 51, DLB-d n = 16, pro-AD n = 33, AD-d n = 32, and AD/DLB-d n = 11) and b CSF concentration of alpha-synuclein in CS, DLB (pro-DLB + DLB-d), AD (pro-AD + AD-d), and AD/DLB (mixed pathologies: pro-AD/DLB + AD/DLB-d). ***P < 0.001; *P < 0.05. P values were calculated using the Kruskal-Wallis test with Dunn’s multiple comparison test. c Alpha-synuclein ROC curve between DLB and AD groups. Prodromal and demented patients were pooled in each group. Number of patients per group: DLB n = 67, AD n = 65. Se, sensitivity; Sp, specificity

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Alzheimer's Research & Therapy

ISSN: 1758-9193