| |
ACE cohort
|
Heidelberg/Mannheim cohort
|
Meta-analysis
|
|---|
|
β
|
SE
|
P value
|
β
|
SE
|
P value
|
β
|
SE
|
Direction
|
P value
|
FDR
|
|---|
|
LPA C20:1
|
0.350
|
0.086
|
8.16 × 10−5
|
0.333
|
0.174
|
6.42 × 10−2
|
0.347
|
0.077
|
++
|
7.11 × 10−6
|
8.25 × 10−5
|
|
Isomer-LPA C22:5
|
0.302
|
0.082
|
3.15 × 10−4
|
0.438
|
0.170
|
1.46 × 10−2
|
0.328
|
0.074
|
++
|
8.68 × 10−6
|
8.25 × 10−5
|
|
LPA C22:6
|
0.279
|
0.083
|
9.39 × 10−4
|
0.214
|
0.198
|
2.88 × 10−1
|
0.270
|
0.076
|
++
|
4.03 × 10−4
|
2.55 × 10−3
|
|
LPA C16:0
|
0.218
|
0.080
|
7.67 × 10−3
|
0.316
|
0.214
|
1.48 × 10−1
|
0.230
|
0.075
|
++
|
2.26 × 10−3
|
1.07 × 10−2
|
|
LPA C16:1
|
0.226
|
0.086
|
9.49 × 10−3
|
0.112
|
0.182
|
5.43 × 10−1
|
0.206
|
0.078
|
++
|
8.23 × 10−3
|
3.13 × 10−2
|
|
LPA C22:4
|
0.168
|
0.082
|
4.17 × 10−2
|
0.287
|
0.196
|
1.53 × 10−1
|
0.186
|
0.076
|
++
|
1.39 × 10−2
|
4.40 × 10−2
|
|
LPA C18:1
|
0.217
|
0.099
|
3.08 × 10−2
|
0.171
|
0.212
|
4.25 × 10−1
|
0.209
|
0.090
|
++
|
2.04 × 10−2
|
5.54 × 10−2
|
|
aLPA C18:1
|
0.110
|
0.128
|
3.91 × 10−1
|
0.425
|
0.169
|
1.69 × 10−2
|
0.224
|
0.102
|
++
|
2.79 × 10−2
|
6.62 × 10−2
|
|
cLPA C18:0
|
0.159
|
0.089
|
7.53 × 10−2
|
0.243
|
0.197
|
2.26 × 10−1
|
0.173
|
0.081
|
++
|
3.23 × 10−2
|
6.82 × 10−2
|
|
LPA C20:3
|
0.072
|
0.101
|
4.79 × 10−1
|
0.380
|
0.163
|
2.62 × 10−2
|
0.157
|
0.086
|
++
|
6.77 × 10−2
|
1.29 × 10−1
|
|
cLPA C18:1
|
0.115
|
0.092
|
2.14 × 10−1
|
0.265
|
0.189
|
1.69 × 10−1
|
0.144
|
0.083
|
++
|
8.25 × 10−2
|
1.42 × 10−1
|
|
LPA C14:0
|
0.129
|
0.091
|
1.60 × 10−1
|
0.088
|
0.187
|
6.42 × 10−1
|
0.121
|
0.082
|
++
|
1.40 × 10–1
|
2.12 × 10−1
|
|
LPA C22:5
|
0.065
|
0.087
|
4.56 × 10−1
|
0.326
|
0.184
|
8.51 × 10−2
|
0.112
|
0.078
|
++
|
1.52 × 10−1
|
2.12 × 10−1
|
|
aLPA C16:1
|
0.061
|
0.131
|
6.42 × 10−1
|
0.287
|
0.168
|
9.65 × 10−2
|
0.146
|
0.103
|
++
|
1.56 × 10−1
|
2.12 × 10−1
|
|
LPA C18:0
|
0.096
|
0.089
|
2.82 × 10−1
|
0.077
|
0.188
|
6.86 × 10−1
|
0.092
|
0.080
|
++
|
2.50 × 10−1
|
3.16 × 10−1
|
|
LPA C18:2
|
− 0.094
|
0.083
|
2.60 × 10−1
|
−0.024
|
0.175
|
8.90 × 10−1
|
− 0.081
|
0.075
|
–
|
2.79 × 10−1
|
3.30 × 10−1
|
|
cLPA C16:0
|
0.102
|
0.104
|
3.28 × 10−1
|
0.075
|
0.196
|
7.04 × 10−1
|
0.096
|
0.092
|
++
|
2.95 × 10−1
|
3.30 × 10−1
|
|
LPA C20:4
|
0.077
|
0.095
|
4.20 × 10−1
|
0.081
|
0.176
|
6.49 × 10−1
|
0.078
|
0.084
|
++
|
3.53 × 10−1
|
3.72 × 10−1
|
|
LPA C20:5
|
− 0.028
|
0.088
|
7.54 × 10−1
|
0.114
|
0.193
|
5.59 × 10−1
|
− 0.003
|
0.081
|
−+
|
9.68 × 10−1
|
9.68 × 10−1
|
- Direction column indicates the direction of regression coefficient of association in the ACE and Heidelberg/Mannheim cohort respectively
- Abbreviations: LPA lysophosphatidic acid, cLPA cyclic lysophosphatidic acid, aLPA alkyl-Lysophosphatidic acid, SE standard error, FDR false discovery rate
