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Table 3 Association of cerebrospinal fluid (CSF) level of metabolites with p-tau levels in CSF

From: Association of lysophosphatidic acids with cerebrospinal fluid biomarkers and progression to Alzheimer’s disease

  ACE cohort Heidelberg/Mannheim cohort Meta-analysis
β SE P value β SE P value β SE Direction P value FDR
LPA C20:1 0.350 0.086 8.16 × 10−5 0.333 0.174 6.42 × 10−2 0.347 0.077 ++ 7.11 × 10−6 8.25 × 10−5
Isomer-LPA C22:5 0.302 0.082 3.15 × 10−4 0.438 0.170 1.46 × 10−2 0.328 0.074 ++ 8.68 × 10−6 8.25 × 10−5
LPA C22:6 0.279 0.083 9.39 × 10−4 0.214 0.198 2.88 × 10−1 0.270 0.076 ++ 4.03 × 10−4 2.55 × 10−3
LPA C16:0 0.218 0.080 7.67 × 10−3 0.316 0.214 1.48 × 10−1 0.230 0.075 ++ 2.26 × 10−3 1.07 × 10−2
LPA C16:1 0.226 0.086 9.49 × 10−3 0.112 0.182 5.43 × 10−1 0.206 0.078 ++ 8.23 × 10−3 3.13 × 10−2
LPA C22:4 0.168 0.082 4.17 × 10−2 0.287 0.196 1.53 × 10−1 0.186 0.076 ++ 1.39 × 10−2 4.40 × 10−2
LPA C18:1 0.217 0.099 3.08 × 10−2 0.171 0.212 4.25 × 10−1 0.209 0.090 ++ 2.04 × 10−2 5.54 × 10−2
aLPA C18:1 0.110 0.128 3.91 × 10−1 0.425 0.169 1.69 × 10−2 0.224 0.102 ++ 2.79 × 10−2 6.62 × 10−2
cLPA C18:0 0.159 0.089 7.53 × 10−2 0.243 0.197 2.26 × 10−1 0.173 0.081 ++ 3.23 × 10−2 6.82 × 10−2
LPA C20:3 0.072 0.101 4.79 × 10−1 0.380 0.163 2.62 × 10−2 0.157 0.086 ++ 6.77 × 10−2 1.29 × 10−1
cLPA C18:1 0.115 0.092 2.14 × 10−1 0.265 0.189 1.69 × 10−1 0.144 0.083 ++ 8.25 × 10−2 1.42 × 10−1
LPA C14:0 0.129 0.091 1.60 × 10−1 0.088 0.187 6.42 × 10−1 0.121 0.082 ++ 1.40 × 10–1 2.12 × 10−1
LPA C22:5 0.065 0.087 4.56 × 10−1 0.326 0.184 8.51 × 10−2 0.112 0.078 ++ 1.52 × 10−1 2.12 × 10−1
aLPA C16:1 0.061 0.131 6.42 × 10−1 0.287 0.168 9.65 × 10−2 0.146 0.103 ++ 1.56 × 10−1 2.12 × 10−1
LPA C18:0 0.096 0.089 2.82 × 10−1 0.077 0.188 6.86 × 10−1 0.092 0.080 ++ 2.50 × 10−1 3.16 × 10−1
LPA C18:2 − 0.094 0.083 2.60 × 10−1 −0.024 0.175 8.90 × 10−1 − 0.081 0.075 2.79 × 10−1 3.30 × 10−1
cLPA C16:0 0.102 0.104 3.28 × 10−1 0.075 0.196 7.04 × 10−1 0.096 0.092 ++ 2.95 × 10−1 3.30 × 10−1
LPA C20:4 0.077 0.095 4.20 × 10−1 0.081 0.176 6.49 × 10−1 0.078 0.084 ++ 3.53 × 10−1 3.72 × 10−1
LPA C20:5 − 0.028 0.088 7.54 × 10−1 0.114 0.193 5.59 × 10−1 − 0.003 0.081 −+ 9.68 × 10−1 9.68 × 10−1
  1. Direction column indicates the direction of regression coefficient of association in the ACE and Heidelberg/Mannheim cohort respectively
  2. Abbreviations: LPA lysophosphatidic acid, cLPA cyclic lysophosphatidic acid, aLPA alkyl-Lysophosphatidic acid, SE standard error, FDR false discovery rate