Fig. 4

Relationship between mean diffusivity and estimated years to/from symptom onset in mutation carriers. Graphs show linear regression of MD against EYO after adjusting for cortical thickness and including a quadratic term for EYO in all models for consistency. For each region, cortical thickness was set at the mean value for the study sample for that region: entorhinal (2.75 mm), inferior parietal (2.20 mm), precuneus (2.14 mm), superior frontal (2.32 mm), superior parietal (1.91 mm) and supramarginal (2.30 mm). The p value is from a test of the association between MD and EYO after adjusting for cortical thickness. MD, mean diffusivity; EYO, estimated years to/from symptom onset