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Table 3 Exploratory univariable analyses for the association between extracranial carotid and intracranial arterial stenosis and AD biomarkers in the CN group

From: Association of carotid and intracranial stenosis with Alzheimer’s disease biomarkers

AD biomarker Variables Presence of any detectable stenosis
   Any extracranial carotid stenosis Any intracranial stenosis
   Stenosis− Stenosis+ p value da Stenosis− Stenosis+ p value d
Aβ biomarker Global Aβ 1.185 ± 0.245 1.173 ± 0.160 0.810 0.052 1.182 ± 0.243 1.190 ± 0.230 0.782 − 0.037
Neurodegeneration biomarker AD-CT 2.877 ± 0.170 2.743 ± 0.173 < 0.001* 0.786 2.890 ± 0.171 2.804 ± 0.165 < 0.001* 0.505
HVa − 732 ± 810 − 1067 ± 1076 0.066 0.401 − 686 ± 832 − 953 ± 0827 0.017* 0.322
   Presence of stenosis based on severity threshold
   ≥ 50% intracranial stenosisb Number of stenotic intracranial arteries ≥ 2c
   Stenosis− Stenosis+ p value d Stenosis− Stenosis+ p value d
Aβ biomarker Global Aβ 1.179 ± 0.234 1.258 ± 0.293 0.165 − 0.331 1.189 ± 0.242 1.157 ± 0.221 0.409 0.136
Neurodegeneration biomarker AD-CT 2.871 ± 0.175 2.801 ± 0.136 0.091 0.403 2.882 ± 0.169 2.780 ± 0.178 < 0.001* 0.603
HVa − 746 ± 838 − 937 ± 837 0.338 0.228 − 726 ± 840 − 938 ± 810 0.123 0.254
   Presence of stenosis according to location
   Anterior circulation Posterior circulation
   Stenosis− Stenosis+ p value d Stenosis− Stenosis+ p value d
Aβ biomarker Global Aβ 1.187 ± 0.245 1.175 ± 0.220 0.711 0.052 1.185 ± 0.241 1.175 ± 0.212 0.854 0.042
Neurodegeneration biomarker AD-CT 2.884 ± 0.172 2.811 ± 0.167 0.002* 0.428 2.876 ± 0.170 2.744 ± 0.181 0.001* 0.772
HVa − 710 ± 837 − 911 ± 828 0.082 0.242 − 760 ± 836 − 746 ± 875 0.943 − 0.016
  1. Data for continuous variables presented as means ± SD (SUVR for global Aβ, mm for AD-CT, and mm3 for HVa)
  2. CN cognitively normal, SUVR standardized uptake value ratio, AD-CT Alzheimer’s disease-signature cortical thickness, HVa hippocampal volume adjusted for intracranial volume
  3. ad indicates Cohen’s delta
  4. b“Stenosis−” group of “≥ 50% intracranial stenosis” means individuals with no stenosis or < 50% intracranial stenosis
  5. c“Stenosis−” group of “number of stenotic intracranial arteries ≥ 2” means patients with no stenosis or only one stenotic intracranial artery
  6. *p < 0.05