Association of carotid and intracranial stenosis with Alzheimer’s disease biomarkers

Kang, Koung Mi; Byun, Min Soo; Lee, Jun Ho; Yi, Dahyun; Choi, Hye Jeong; Lee, Eunjung; Lee, Younghwa; Lee, Jun-Young; Kim, Yu Kyeong; Sohn, Bo Kyung; Sohn, Chul-Ho; Lee, Dong Young

doi:10.1186/s13195-020-00675-6

Alzheimer's Research & Therapy

Table 3 Exploratory univariable analyses for the association between extracranial carotid and intracranial arterial stenosis and AD biomarkers in the CN group

From: Association of carotid and intracranial stenosis with Alzheimer’s disease biomarkers

AD biomarker	Variables	Presence of any detectable stenosis
		Any extracranial carotid stenosis				Any intracranial stenosis
		Stenosis−	Stenosis+	p value	d^a	Stenosis−	Stenosis+	p value	d
Aβ biomarker	Global Aβ	1.185 ± 0.245	1.173 ± 0.160	0.810	0.052	1.182 ± 0.243	1.190 ± 0.230	0.782	− 0.037
Neurodegeneration biomarker	AD-CT	2.877 ± 0.170	2.743 ± 0.173	< 0.001*	0.786	2.890 ± 0.171	2.804 ± 0.165	< 0.001*	0.505
Neurodegeneration biomarker	HVa	− 732 ± 810	− 1067 ± 1076	0.066	0.401	− 686 ± 832	− 953 ± 0827	0.017*	0.322
		Presence of stenosis based on severity threshold
		≥ 50% intracranial stenosis^b				Number of stenotic intracranial arteries ≥ 2^c
		Stenosis−	Stenosis+	p value	d	Stenosis−	Stenosis+	p value	d
Aβ biomarker	Global Aβ	1.179 ± 0.234	1.258 ± 0.293	0.165	− 0.331	1.189 ± 0.242	1.157 ± 0.221	0.409	0.136
Neurodegeneration biomarker	AD-CT	2.871 ± 0.175	2.801 ± 0.136	0.091	0.403	2.882 ± 0.169	2.780 ± 0.178	< 0.001*	0.603
Neurodegeneration biomarker	HVa	− 746 ± 838	− 937 ± 837	0.338	0.228	− 726 ± 840	− 938 ± 810	0.123	0.254
		Presence of stenosis according to location
		Anterior circulation				Posterior circulation
		Stenosis−	Stenosis+	p value	d	Stenosis−	Stenosis+	p value	d
Aβ biomarker	Global Aβ	1.187 ± 0.245	1.175 ± 0.220	0.711	0.052	1.185 ± 0.241	1.175 ± 0.212	0.854	0.042
Neurodegeneration biomarker	AD-CT	2.884 ± 0.172	2.811 ± 0.167	0.002*	0.428	2.876 ± 0.170	2.744 ± 0.181	0.001*	0.772
Neurodegeneration biomarker	HVa	− 710 ± 837	− 911 ± 828	0.082	0.242	− 760 ± 836	− 746 ± 875	0.943	− 0.016

Data for continuous variables presented as means ± SD (SUVR for global Aβ, mm for AD-CT, and mm³ for HVa)
CN cognitively normal, SUVR standardized uptake value ratio, AD-CT Alzheimer’s disease-signature cortical thickness, HVa hippocampal volume adjusted for intracranial volume
^ad indicates Cohen’s delta
^b“Stenosis−” group of “≥ 50% intracranial stenosis” means individuals with no stenosis or < 50% intracranial stenosis
^c“Stenosis−” group of “number of stenotic intracranial arteries ≥ 2” means patients with no stenosis or only one stenotic intracranial artery
*p < 0.05

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ISSN: 1758-9193

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