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Table 4 Differences in LAS-FNAME performance between symptomatic PSEN1 mutation carriers and non-carriers

From: The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease

 

Non-carriers (n = 48)

Symptomatic carriers (n = 19)

LAS-FNAME

M (SD)

M (SD)

df

F

p valuea

d

Immediate Memory

 Face Recognition

11.71 (.79)

10.84 (1.71)

1, 111

2.53

.114

.38

 Letter Recall

4.88 (2.60)

2.84 (1.89)

1, 111

5.25

.024*

.49

 Name Recognition

9.83 (1.70)

7.00 (2.21)

1, 111

18.61

.000*

.86

Delayed Memory

 Face Recognition

11.81 (.53)

10.58 (1.80)

1, 111

3.68

.058

.47

 Letter Recall

6.06 (2.98)

3.11 (2.05)

1, 111

11.12

.001*

.70

 Name Recognition

9.27 (2.39)

7.11 (1.91)

1, 111

6.71

.011*

.52

Scale Scores

 IM Total

26.42 (4.19)

20.68 (4.40)

1, 111

12.58

.001*

.75

 DM Total

27.14 (4.88)

20.79 (4.43)

1, 111

11.45

.001*

.71

 LAS-FNAME Total

53.56 (8.76)

41.47 (8.32)

1, 111

12.77

.001*

.76

  1. Note: Symptomatic carriers include participants with FAST scores of 2 and 3 indicating presence of subjective cognitive concerns and mild cognitive impairment, respectively
  2. Abbreviations: M mean, SD standard deviation, IM Immediate Memory, DM Delayed Memory, LAS-FNAME Total IM Total + DM Total, df degrees of freedom, F F-ratio, d Cohen’s d effect size
  3. ap value calculated for ANOVA tests for all PSEN1 mutation carriers (i.e., cognitively intact, subjective cognitive concerns, and mild cognitive impairment) versus non-carriers
  4. *p < 0.05
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Alzheimer's Research & Therapy

ISSN: 1758-9193