| |
Non-carriers (n = 48)
|
Symptomatic carriers (n = 19)
|
|---|
|
LAS-FNAME
|
M (SD)
|
M (SD)
|
df
|
F
|
p valuea
|
d
|
|---|
|
Immediate Memory
|
|
Face Recognition
|
11.71 (.79)
|
10.84 (1.71)
|
1, 111
|
2.53
|
.114
|
.38
|
|
Letter Recall
|
4.88 (2.60)
|
2.84 (1.89)
|
1, 111
|
5.25
|
.024*
|
.49
|
|
Name Recognition
|
9.83 (1.70)
|
7.00 (2.21)
|
1, 111
|
18.61
|
.000*
|
.86
|
|
Delayed Memory
|
|
Face Recognition
|
11.81 (.53)
|
10.58 (1.80)
|
1, 111
|
3.68
|
.058
|
.47
|
|
Letter Recall
|
6.06 (2.98)
|
3.11 (2.05)
|
1, 111
|
11.12
|
.001*
|
.70
|
|
Name Recognition
|
9.27 (2.39)
|
7.11 (1.91)
|
1, 111
|
6.71
|
.011*
|
.52
|
|
Scale Scores
|
|
IM Total
|
26.42 (4.19)
|
20.68 (4.40)
|
1, 111
|
12.58
|
.001*
|
.75
|
|
DM Total
|
27.14 (4.88)
|
20.79 (4.43)
|
1, 111
|
11.45
|
.001*
|
.71
|
|
LAS-FNAME Total
|
53.56 (8.76)
|
41.47 (8.32)
|
1, 111
|
12.77
|
.001*
|
.76
|
- Note: Symptomatic carriers include participants with FAST scores of 2 and 3 indicating presence of subjective cognitive concerns and mild cognitive impairment, respectively
- Abbreviations: M mean, SD standard deviation, IM Immediate Memory, DM Delayed Memory, LAS-FNAME Total IM Total + DM Total, df degrees of freedom, F F-ratio, d Cohen’s d effect size
- ap value calculated for ANOVA tests for all PSEN1 mutation carriers (i.e., cognitively intact, subjective cognitive concerns, and mild cognitive impairment) versus non-carriers
- *p < 0.05
