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Table 1 Demographic, cognitive, and clinical characteristics of the sample

From: The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease

  Non-carriers (n = 48) Cognitively intact carriers (n = 35) pa Symptomatic carriers (n = 19) pb
M (SD) M (SD) M (SD)
Demographic and clinical variables
 Age (years) 34.43 (4.32) 32.14 (3.73) .018* 40.63 (4.92) .557
 Education (years) 10.45 (4.19) 10.72 (3.68) .769 7.16 (3.84) .259
 MMSE 28.94 (.88) 28.67 (.93) .199 25.63 (3.17) .001*
 GDS 1.00 (.00) 1.03 (.00) 1.000 2.84 (3.35) .798
Cognitive variables
 CERAD Word List Learning 20.63 (2.98) 20.28 (3.54) .799 13.84 (4.39) .007*
 CERAD Word List Delayed Recall 7.67 (1.26) 7.31 (1.58) .534 3.74 (2.64) .002*
 CERAD Word List Recognition 9.71 (.58) 9.81 (.47) .486 7.95 (2.20) .034*
 CERAD Constructional Praxis-Copy 10.41 (.89) 10.25 (.91) .346 9.53 (1.12) .030*
 CERAD Constructional Praxis-Delayed Recall 9.57 (1.70) 9.72 (1.52) .744 4.63 (3.48) .036*
 Phonemic Fluency (FAS) 32.41 (7.33) 34.53 (7.89) .212 31.47 (10.38) .868
 Semantic Fluency (Animals) 20.37 (4.01) 21.31 (4.20) .233 18.74 (3.97) .888
 Boston Naming Test (BNT-15) 13.82 (.95) 13.33 (1.24) .055 12.95 (1.71) .023*
PET variables^
 Amyloid (Aβ) (DVR) 1.11 (0.04) 1.45 (.24) .000* 1.93 (.30) .000*
 Entorhinal cortex tau (SUVR) 1.05 (0.21) 1.34 (.42) .054 2.10 (.70) .000*
 Inferior temporal cortex tau (SUVR) 1.18 (0.11) 1.23 (.16) .108 1.72 (.46) .001*
  1. Note: Symptomatic carriers include participants with FAST scores of 2 and 3 indicating presence of SCD and MCI, respectively
  2. Abbreviations: M mean, SD standard deviation, FAST Functional Assessment Staging test, MMSE Mini Mental State Exam, GDS Geriatric Depression Scale, CERAD Consortium to Establish a Registry for Alzheimer’s Disease, DVR distribution volume ratio, SUVR standardized uptake value ratio
  3. ^From subset participants with PET data. All PET values were partial volume corrected (PVC)
  4. ap value calculated for Mann-Whitney test for cognitively intact PSEN1 mutation carriers versus non-carriers
  5. bp value calculated for Mann-Whitney test for all PSEN1 mutation carriers (i.e., cognitively intact, SCD, and MCI) versus non-carriers
  6. *p < 0.05. Group differences significant at the 0.05 level (2-tailed)