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Table 1 Demographic, cognitive, and clinical characteristics of the sample

From: The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer’s disease

 

Non-carriers (n = 48)

Cognitively intact carriers (n = 35)

pa

Symptomatic carriers (n = 19)

pb

M (SD)

M (SD)

M (SD)

Demographic and clinical variables

 Age (years)

34.43 (4.32)

32.14 (3.73)

.018*

40.63 (4.92)

.557

 Education (years)

10.45 (4.19)

10.72 (3.68)

.769

7.16 (3.84)

.259

 MMSE

28.94 (.88)

28.67 (.93)

.199

25.63 (3.17)

.001*

 GDS

1.00 (.00)

1.03 (.00)

1.000

2.84 (3.35)

.798

Cognitive variables

 CERAD Word List Learning

20.63 (2.98)

20.28 (3.54)

.799

13.84 (4.39)

.007*

 CERAD Word List Delayed Recall

7.67 (1.26)

7.31 (1.58)

.534

3.74 (2.64)

.002*

 CERAD Word List Recognition

9.71 (.58)

9.81 (.47)

.486

7.95 (2.20)

.034*

 CERAD Constructional Praxis-Copy

10.41 (.89)

10.25 (.91)

.346

9.53 (1.12)

.030*

 CERAD Constructional Praxis-Delayed Recall

9.57 (1.70)

9.72 (1.52)

.744

4.63 (3.48)

.036*

 Phonemic Fluency (FAS)

32.41 (7.33)

34.53 (7.89)

.212

31.47 (10.38)

.868

 Semantic Fluency (Animals)

20.37 (4.01)

21.31 (4.20)

.233

18.74 (3.97)

.888

 Boston Naming Test (BNT-15)

13.82 (.95)

13.33 (1.24)

.055

12.95 (1.71)

.023*

PET variables^

 Amyloid (Aβ) (DVR)

1.11 (0.04)

1.45 (.24)

.000*

1.93 (.30)

.000*

 Entorhinal cortex tau (SUVR)

1.05 (0.21)

1.34 (.42)

.054

2.10 (.70)

.000*

 Inferior temporal cortex tau (SUVR)

1.18 (0.11)

1.23 (.16)

.108

1.72 (.46)

.001*

  1. Note: Symptomatic carriers include participants with FAST scores of 2 and 3 indicating presence of SCD and MCI, respectively
  2. Abbreviations: M mean, SD standard deviation, FAST Functional Assessment Staging test, MMSE Mini Mental State Exam, GDS Geriatric Depression Scale, CERAD Consortium to Establish a Registry for Alzheimer’s Disease, DVR distribution volume ratio, SUVR standardized uptake value ratio
  3. ^From subset participants with PET data. All PET values were partial volume corrected (PVC)
  4. ap value calculated for Mann-Whitney test for cognitively intact PSEN1 mutation carriers versus non-carriers
  5. bp value calculated for Mann-Whitney test for all PSEN1 mutation carriers (i.e., cognitively intact, SCD, and MCI) versus non-carriers
  6. *p < 0.05. Group differences significant at the 0.05 level (2-tailed)
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Alzheimer's Research & Therapy

ISSN: 1758-9193