Skip to main content

Table 1 Characteristics of the population study

From: CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer’s disease

Characteristics Overall (N = 162) Controls (N = 27) AD (N = 54) MCI-AD (N = 20) Other MCI (N = 31) Other dementias (N = 30) p value
Age, years, mean (SD) 66.6 (9.5) 62.0 (11.3) 69.4 (7.9) 70.2 (8.0) 61.5 (9.6) 68.7 (7.6) < 0.001
Women, n (%) 90 (55.6) 23 (85.2) 33 (61.1) 12 (60.0) 11 (35.5) 11 (36.7) < 0.001
MMSE, mean, (SD) 23.4 (4.9) 26.0 (3.3) 20.3 (4.7) 27.0 (1.7) 25.8 (2.8) 22.0 (5.4) < 0.001
Baccalaureate degree or higher, n (%) 64 (44.8) 13 (56.5) 18 (37.5) 12 (66.7) 11 (37.9) 10 (40.0) 0.05
APOE ε4carriers, n (%)a 65 (43.9) 4 (16.0) 33 (64.7) 7 (38.9) 8 (30.8) 13 (46.4) < 0.001
CSF biomarkers, pg/mL, mean (SD)
 CSF Aβ1–42 751.1 (290.8) 951.9 (285.6) 548.3 (153.6) 695.5 (270.6) 930.0 (287.3) 787.5 (261.1) < 0.001
 CSF Aβ1–40 11,920 (5613) 10,698 (5078) 14,276 (5846) 14,223 (7197) 10,788 (3624) 8202 (3122) < 0.001
 CSF Aβ42/40 ratio 0.076 (0.042) 0.10 (0.047) 0.043 (0.015) 0.053 (0.012) 0.094 (0.031) 0.11 (0.043) < 0.001
 CSF tau 400.0 (272.7) 192.5 (76.3) 664.2 (264.8) 478.5 (139.3) 208.2 (69.7) 256.9 (164.7) < 0.001
 CSF P-tau 60.7 (32.0) 34.7 (11.1) 92.4 (27.5) 76.3 (14.5) 38.5 (10.8) 39.8 (17.4) < 0.001
 CSF BACE1 116.9 (42.0) 99.3 (30.4) 140.0 (46.0) 134.6 (38.3) 106.4 (29.6) 89.3 (28.8) < 0.001
 CSF NRG1 320.1 (134.2) 267.7 (104.2) 364.7 (149.2) 342.6 (161.5) 304.9 (113.0) 287.5 (106.5) 0.01
  1. aAPOE was missing for n = 14 participants