Table 1 Characteristics of the population study
From: CSF levels of the BACE1 substrate NRG1 correlate with cognition in Alzheimer’s disease
Characteristics | Overall (N = 162) | Controls (N = 27) | AD (N = 54) | MCI-AD (N = 20) | Other MCI (N = 31) | Other dementias (N = 30) | p value |
|---|---|---|---|---|---|---|---|
Age, years, mean (SD) | 66.6 (9.5) | 62.0 (11.3) | 69.4 (7.9) | 70.2 (8.0) | 61.5 (9.6) | 68.7 (7.6) | < 0.001 |
Women, n (%) | 90 (55.6) | 23 (85.2) | 33 (61.1) | 12 (60.0) | 11 (35.5) | 11 (36.7) | < 0.001 |
MMSE, mean, (SD) | 23.4 (4.9) | 26.0 (3.3) | 20.3 (4.7) | 27.0 (1.7) | 25.8 (2.8) | 22.0 (5.4) | < 0.001 |
Baccalaureate degree or higher, n (%) | 64 (44.8) | 13 (56.5) | 18 (37.5) | 12 (66.7) | 11 (37.9) | 10 (40.0) | 0.05 |
APOE ε4carriers, n (%)a | 65 (43.9) | 4 (16.0) | 33 (64.7) | 7 (38.9) | 8 (30.8) | 13 (46.4) | < 0.001 |
CSF biomarkers, pg/mL, mean (SD) | |||||||
CSF Aβ1–42 | 751.1 (290.8) | 951.9 (285.6) | 548.3 (153.6) | 695.5 (270.6) | 930.0 (287.3) | 787.5 (261.1) | < 0.001 |
CSF Aβ1–40 | 11,920 (5613) | 10,698 (5078) | 14,276 (5846) | 14,223 (7197) | 10,788 (3624) | 8202 (3122) | < 0.001 |
CSF Aβ42/40 ratio | 0.076 (0.042) | 0.10 (0.047) | 0.043 (0.015) | 0.053 (0.012) | 0.094 (0.031) | 0.11 (0.043) | < 0.001 |
CSF tau | 400.0 (272.7) | 192.5 (76.3) | 664.2 (264.8) | 478.5 (139.3) | 208.2 (69.7) | 256.9 (164.7) | < 0.001 |
CSF P-tau | 60.7 (32.0) | 34.7 (11.1) | 92.4 (27.5) | 76.3 (14.5) | 38.5 (10.8) | 39.8 (17.4) | < 0.001 |
CSF BACE1 | 116.9 (42.0) | 99.3 (30.4) | 140.0 (46.0) | 134.6 (38.3) | 106.4 (29.6) | 89.3 (28.8) | < 0.001 |
CSF NRG1 | 320.1 (134.2) | 267.7 (104.2) | 364.7 (149.2) | 342.6 (161.5) | 304.9 (113.0) | 287.5 (106.5) | 0.01 |