Fig. 4

Circadian wake and sleep differences between strains of mice. Percent time in wakefulness, NREM sleep and REM sleep from a 48-h recording period at 32 weeks of age (n = 9–13) (a, b, and c respectively). Average difference in NREM sleep between light and dark period from 1-week recording periods every 4 weeks (n = 12–23) (d). Asterisks (*) denote statistical significance (p < 0.05) at the time point between WT vs Tg, ^†WT vs Tg+DOX, ^‡WT vs tTA, ^¥Tg vs Tg+DOX, ^¢Tg vs tTA and ^¤Tg+DOX vs tTA