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Table 1 Demographic characteristics of the included studies

From: Testing whether the progression of Alzheimer’s disease changes with the year of publication, additional design, and geographical area: a modeling analysis of literature aggregate data

 OverallTrial with non-add-on designTrial with add-on designTrials before 2008Trials after 2008
Number of trials140113276476
Total sample size19,21014,5564654700812,202
Sample size per arm*102 (11, 746)100 (11, 746)132 (21, 479)107 (14, 327)101 (11, 746)
Age, years*73.5 (58.0, 81.7)73.3 (58.0, 81.7)74.1 (68.0, 79.4)73.2 (58.0, 78.9)73.6 (64.6, 81.7)
Gender, male (%)*42.1 (0, 98.0)41.2 (0,67)43.3 (0, 98.0)42.6 (27.1, 67.0)41.9 (0, 98.0)
Race, white (%)*93.7 (0, 100)93.1 (0, 100)94.1 (0, 100)92.6 (0, 100)94.1 (0, 100)
APOE ε4 carrier, %*58.4 (0, 100)58.1 (0, 100)58.3 (46.6, 74.0)60.0 (53.0, 67.6)57.9 (0, 100)
ADAS-cog 11, points*24.5 (13.1, 39.3)24.8 (13.1, 39.3)24.1 (17.6, 28.0)26.4 (16.2, 39.3)24.0 (13.1, 32.2)
NPI score, points*9.3 (5.0, 21.8)9.6 (5.0, 21.1)9.0 (5.8, 21.8)11.0 (8.7, 16.1)9.1 (5.0, 21.8)
MMSE score, points*19.4 (13.2, 25.4)19.4 (13.2 25.4)19.5 (15.6, 22.2)19.1 (13.2, 22.5)20.1 (15.6, 25.4)
Publication year, no. (%)
 Before 200864 (45.7)64 (61.2)0 (0)
 After 200876 (54.3)49 (38.8)27 (100)
  1. *Reported mean data were express as median (minimum–maximum)