Fig. 1
From: APOE ε4 genotype-dependent cerebrospinal fluid proteomic signatures in Alzheimer’s disease
Left, heatmap of proteins associated with amyloid pathology. Columns indicate APOE ε4 carriers and non-carriers with AD according to the severity of their cognitive impairment (MMSE > 27, 27–24, or < 24). Color scale indicates the Z value of proteins showing a significant difference (p < .05) compared with the control group (APOE ε4 non-carriers with normal amyloid and MMSE > 27). Proteins are expressed as Z-scores using the control group as a reference and plotted when showing a significant difference (p < .05). Light blue indicates non-significance (p > .05). Right, the percentage of proteins associated with one of the 11 biological process categories. Percentages were calculated with disease stage-specific total numbers of proteins associated with abnormal amyloid, and the number of proteins is given below each disease stage. Please see supplementary table 3 for a detailed description of biological processes enriched