Table 1 Statistically significant correlations detected for individual proteins quantified at different disease Braak stages in brain extracellular vesicles (EVs) and remaining brain tissues
Protein gene symbol | Correlated variables | Correlation coefficient* | p value | Potential interpretation** | |
|---|---|---|---|---|---|
MAG | AD5 WB | AD6 EVs | 0.99 | 0.040 | Degradation by EVs |
GMFB | AD3 WB | AD4 EVs | 0.99 | 0.048 | Preclinical and early symptomatic rescue response in EVs |
AD3 WB | AD6 EVs | 0.99 | 0.049 | – | |
GABARAPL | AD3 WB | AD3 EVs | 0.99 | 0.041 | – |
AD3 EVs | AD4 WB | 1.00 | 0.003 | Preclinical encapsulation in EVs | |
AD3 EVs | AD5 WB | 1.00 | 0.013 | Preclinical encapsulation in EVs | |
AD3 EVs | AD6 EVs | 0.86 | 0.003 | Abnormal uptaking late stage AD | |
Lamp1 | AD3 EVs | AD4 WB | 0.99 | 0.039 | Ongoing Lamp1 synthesis during AD progression. Abnormal Lamp1 inclusion in lysosomes in AD progression |
AD3 EVs | AD5 WB | 1.00 | 0.020 | ||
AD3 EVs | AD6 WB | 0.99 | 0.036 | ||
GAP43 | AD3 WB | AD4 EVs | 0.99 | 0.046 | Preclinical and early symptomatic rescue response in EVs |