Fig. 2

Analysis of brain EV biogenesis in AD. a Analysis of the total number of proteins identified from brain EV proteomes and remaining whole brain proteomes throughout the progressive course of AD (AD3 to AD6) in front of age-matched controls (control) and mixed dementias (Dem) subjects. b Relative quantitation of MHC class I markers proteins in brain EV. Significant differences were only observed for this family of protein in preclinical AD3 versus age-matched controls. Conditions AD5 and AD6 were not displayed as these did not shown significant differences with age-matched controls. Significant differences versus age-matched controls were analyzed by one-way ANOVA with Bonferroni correction for multiple comparisons. *Significant differences compared to age-matched controls P < 0.05. **Significant differences compared to age-matched controls P < 0.01. c Correlation between brain EV proteomes and MHC class-derived proteins identified in preclinical AD