The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer’s disease

Table 1 Demographic and neuropsychological features in single EOAD patient

	EOAD1	EOAD2	EOAD3	EOAD4	EOAD5	EOAD6	EOAD7	EOAD8	EOAD9	EOAD10	EOAD11	EOAD12
Age, years	68	55	56	64	58	59	64	58	54	56	63	66
Education, years	5	13	13	8	13	8	8	8	8	13	8	5
Sex	F	M	M	F	F	M	F	F	M	F	F	M
Disease duration, years	5	1	1	3	2	1	1	5	1	2	3	2
Diagnosis	tAD	tAD	tAD	tAD	fAD	fAD	fAD	fAD	fAD	fAD	PCA	PCA
MMSE	20	21	17	22	18	10	12	18	17	22	21	21
Token test	31	31	23.5	29	23	11.5	19.25	22.25	33	31	27.5	30.5
PVF	27	10	7	29	16	6	3	13	22	31	56	44
SVF	30.1	8	18.5	42.8	12	16	8	13	45.5	44	29.2	59.2
Span forward	6.39	4.84	2.83	5.13	5.75	6.13	2.92	5.04	2.92	5.83	4.13	6.02
Span backward	4.53	< 3	< 3	3.19	< 3	< 3	< 3	3.1	< 3	3.79	4.19	< 3
RAVLT IR	22.1	14.8	13.8	24.3	10	UT	UT	0	36	41	21.5	32.3
RAVLT DR	0	0	0	0	1.5	UT	UT	0	4.2	4	3	3.6
ROF recall	8	UT	0	8.5	5.25	UT	0	5	5.75	11.75	0	7.5
ROF copy	9	UT	0	23	13.25	3	7.25	28.5	29.25	14.75	0	24.25
CDT	1	10	2	5	5	0	0	0	10	7	0	10
Attentive Matrix	36	UT	12.5	31.25	23	UT	17.5	23	22	49	34.25	23
Stroop time	33.5	28	44.25	36.75	29.25	UT	UT	UT	46.8	46.17	44.25	27
Stroop errors	9.5	3.5	13	11.25	26.5	UT	UT	UT	5	0	5.25	2.5
Raven PM	19.5	UT	14	19	UT	UT	UT	21.5	26.5	22	12	31.5

EOAD early-onset Alzheimer disease, AD Alzheimer disease, tAD typical AD, fAD frontal Alzheimer disease, PCA posterior cortical atrophy, MMSE mini mental state examination, PVF phonological verbal fluency, SVP semantic verbal fluency, RAVLT Rey auditory verbal learning task, IR immediate recall, DR delayed recall, ROF Rey-Osterrieth figure, CDT clock drawing test, Raven PM Raven Progressive Matrices, UT untestable
For neuropsychological assessment, pathological scores are reported in bold