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Table 3 Top 5 S-MultiXcan associations by APOE region

From: An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

GeneTop tissueN tissuesPZ score
MinMaxMeanSD
Inside APOE  
 PVRL2Oesophagus muscularis172.64 × 10−131− 19.285.78− 4.946.75
 APOESkin, sun-exposed leg74.25 × 10−101− 19.507.51− 3.5810.50
 APOC1Adrenal gland44.05 × 10−92− 19.135.98− 6.2413.43
 BLOC1S3Oesophagus muscularis69.00 × 10−75−15.633.48−  1.787.07
 APOC4Adrenal gland41.40 × 10−39− 9.535.91−  0.927.96
Outside APOE  
 SIX5Skin, sun-exposed leg41.24 × 10−37− 6.1810.3− 0.417.40
 VASPTestis35.58 × 10−28− 11.32.61− 2.297.82
 BIN1Oesophagus muscularis233.58 × 10−16− 6.324.09− 2.213.26
 CLUSkin, sun-exposed leg87.51 × 10−14− 3.078.221.284.12
 CR1Oesophagus muscularis71.69 × 10−11− 0.387.334.2993.45
  1. N tissues, number of tissues with significant gene-based association; Z score, minimum, maximum, mean, and standard deviation of the Alzheimer’s disease association coefficient from S-MultiXcan