An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

Table 3 Top 5 S-MultiXcan associations by APOE region

Gene	Top tissue	N tissues	P	Z score
Gene	Top tissue	N tissues	P	Min	Max	Mean	SD
Inside APOE
PVRL2	Oesophagus muscularis	17	2.64 × 10⁻¹³¹	− 19.28	5.78	− 4.94	6.75
APOE	Skin, sun-exposed leg	7	4.25 × 10⁻¹⁰¹	− 19.50	7.51	− 3.58	10.50
APOC1	Adrenal gland	4	4.05 × 10⁻⁹²	− 19.13	5.98	− 6.24	13.43
BLOC1S3	Oesophagus muscularis	6	9.00 × 10⁻⁷⁵	−15.63	3.48	− 1.78	7.07
APOC4	Adrenal gland	4	1.40 × 10⁻³⁹	− 9.53	5.91	− 0.92	7.96
Outside APOE
SIX5	Skin, sun-exposed leg	4	1.24 × 10⁻³⁷	− 6.18	10.3	− 0.41	7.40
VASP	Testis	3	5.58 × 10⁻²⁸	− 11.3	2.61	− 2.29	7.82
BIN1	Oesophagus muscularis	23	3.58 × 10⁻¹⁶	− 6.32	4.09	− 2.21	3.26
CLU	Skin, sun-exposed leg	8	7.51 × 10⁻¹⁴	− 3.07	8.22	1.28	4.12
CR1	Oesophagus muscularis	7	1.69 × 10⁻¹¹	− 0.38	7.33	4.299	3.45

N tissues, number of tissues with significant gene-based association; Z score, minimum, maximum, mean, and standard deviation of the Alzheimer’s disease association coefficient from S-MultiXcan

ISSN: 1758-9193