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Table 1 Top 5 S-PrediXcan associations by APOE region

From: An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer’s disease

GeneChrMost significant tissueSNPsTissuesZ scoreP value
Inside APOE
 APOE19Skin, sun-exposed leg103− 19.501.03 × 10−84
 NECTIN219Oesophagus muscularis38− 19.288.32 × 10− 83
 APOC119Adrenal gland33− 19.131.48 × 10−81
 BLOC1S319Oesophagus muscularis91− 15.634.29 × 10−55
 RELB19Lung24111.557.14 × 10−31
Outside APOE
 VASP19Testis531− 11.301.24 × 10−29
 SIX519Skin, sun-exposed leg40210.288.60 × 10−25
 CD3EAP19Substantia nigra6110.068.65 × 10−24
 ZNF15519Minor salivary gland622− 8.453.02 × 10−17
 CLU2Skin, sun-exposed leg528.222.04 × 10−16
  1. Chr chromosome; N SNPs are the number of eQTLs included in the MetaXcan prediction model; N tissues are the N tissues with P value < 7.63 × 10−7; Z score represents the strength of association between gene expression and disease risk. Positive values indicate that an increased level of gene expression is associated with increased disease risk, while negative values indicate that a reduced level of gene expression increases disease risk