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Table 6 Linear regression analysis output of the association of retinal thickness with FBB global SUVR at v0 and v2

From: Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

 Log-transformed FBB global SUVR at v0Log-transformed FBB global SUVR at v2
B95% CItβpB95% CItβp
Years of education0.001− 0.001–0.0031.040.090.300.001− 0.001–0.0030.810.070.42
Gender0.000− 0.016–0.016− 0.04− 0.0020.980.001− 0.019–0.0210.100.0080.92
Age0.0010.000–0.0032.700.230.008*0.0020.001–0.0043.300.280.004*
APOE ε4 status0.0440.027–0.0615.160.41< 0.001*0.0490.028–0.0704.600.37< 0.001*
OCT image quality0.0010.000–0.0021.730.140.090.0010.000–0.0021.410.110.16
Inner nasal macular thickness0.0010.000–0.0012.950.230.004*0.0010.000–0.0023.270.260.001*
  1. A second step of the linear regression model was executed with log-transformed FBB global SUVR as the outcome, including simultaneously the regions with a significant effect in the previous step (macular ETDRS centre, inner nasal, inner inferior and outer inferior areas for v0, and macular ETDRS centre, inner nasal, inner superior, inner inferior and outer inferior areas for v2) as predictors, separately. In all analysis, years of education, gender, age, APOE ε4 status and OCT retinal image quality were included as adjusting covariates. The output model showed that only retinal thickness in the inner nasal macular sub-region was positively associated with global SUVR, both at v0 and v2
  2. *Statistical significance was set-up at p < 0.05
  3. Abbreviations: APOE apolipoprotein E, FBB florbetaben, CI confidence interval, ETDRS Early Treatment Diabetic Retinopathy Study, OCT optical coherence tomography, OR odds ratio, RNFL retinal nerve fiber layer, SUVR standardized uptake value ratio, v0 baseline visit, v2 visit at 2 years