Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

Table 4 Logistic regression model output of the association of macular retinal thickness with PET status at v0 and v2

	PET status at v0				PET status at v2
	Wald	p	OR	95% CI	Wald	p	OR	95% CI
Years of education	0.003	0.96	1.01	0.84–1.02	0.32	0.57	1.04	0.90–1.21
Gender	0.79	0.37	0.50	0.11–2.29	1.15	0.28	0.52	0.16–1.72
Age	7.00	0.008*	1.20	1.05–1.37	9.59	0.002*	1.17	1.06–1.29
APOE ε4 status	16.03	< 0.001*	32.06	5.87–175.25	10.26	0.001*	6.65	2.09–21.22
OCT retinal image quality	4.03	0.05	1.16	1.00–1.33	1.51	0.22	1.06	0.97–1.16
Inner nasal macular thickness	7.20	0.007*	1.08	1.02–1.14	8.39	0.004*	1.06	1.02–1.11

The five retinal regions that obtained a significant effect in the previous step of the logistic regression model (ETDRS macular centre, inner temporal, inner superior, inner nasal and inner inferior areas) were subsequently analysed together, including education, gender, age, APOE ε4 status and OCT retinal image quality as adjusting variables, separately for v0 and v2. Only inner nasal macular thickness remained as a significant predictor of PET status at v0 and v2, and the obtained model showed that increased thickness in this region at baseline conferred higher probability of a PET status both at v0 and v2
*Statistical significance was set-up at p < 0.05
Abbreviations: APOE apolipoprotein E, CI confidence interval, ETDRS Early Treatment Diabetic Retinopathy Study, OCT optical coherence tomography, OR odds ratio, PET positron emission tomography, v0 baseline visit, v2 follow-up visit at 2 years

ISSN: 1758-9193