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Table 2 Retinal thickness measurements by PET and clinical status

From: Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

 PET status (+/−) at v0PET status (+/−) at v2Clinical status at v2
Aβ−Aβ+Aβ−Aβ+SCDMCI
n114151072211415
FBB global SUVR1.17 ± 0.051.57 ± 0.201.19 ± 0.061.61 ± 0.281.24 ± 0.161.41 ± 0.39
Peripapillary RNFL
 Total100.74 ± 11.8496.90 ± 19.38101.27 ± 11.3395.55 ± 18.40100.123 ± 13.24101.56 ± 10.24
 Temporal74.02 ± 10.6774.23 ± 15.2374.33 ± 10.6072.64 ± 14.0573.84 ± 11.2075.58 ± 11.62
 Superior118.05 ± 19.75118.27 ± 18.64118.85 ± 18.46114.14 ± 24.59118.05 ± 19.91118.26 ± 17.31
 Nasal77.57 ± 16.2874.24 ± 17.8277.96 ± 15.7573.45 ± 19.3777.16 ± 16.7777.41 ± 14.02
 Inferior133.28 ± 17.62128.62 ± 21.0133.89 ± 17.82127.14 ± 18.31132.44 ± 18.50134.97 ± 14.04
 Image quality47.41 ± 7.4246.87 ± 7.4247.52 ± 7.4846.50 ± 7.0247.99 ± 7.1242.44 ± 7.78
ETDRS macula
 Centre249.67 ± 21.63259.91 ± 23.14249.07 ± 21.56259.59 ± 22.32250.03 ± 22.09257.18 ± 20.63
 Inner temporal300.01 ± 15.72305.52 ± 15.55299.56 ± 15.15305.91 ± 17.76300.10 ± 15.63304.80 ± 16.48
 Inner superior312.32 ± 14.54316.96 ± 18.05311.74 ± 14.11318.30 ± 18.07312.43 ± 14.83316.14 ± 16.24
 Inner nasal313.41 ± 14.26321.38 ± 17.62312.81 ± 13.64321.71 ± 18.29313.80 ± 14.89318.35 ± 14.25
 Inner inferior309.64 ± 14.37316.04 ± 18.48309.14 ± 13.87316.46 ± 18.60309.64 ± 14.49316.05 ± 17.70
 Outer temporal254.28 ± 14.26250.72 ± 15.70254.22 ± 14.10252.15 ± 16.11253.75 ± 14.00254.75 ± 17.81
 Outer superior269.66 ± 12.92266.47 ± 16.49269.48 ± 12.90268.36 ± 15.65269.28 ± 12.84269.34 ± 17.27
 Outer nasal285.87 ± 14.42288.58 ± 18.38285.80 ± 14.03288.05 ± 18.71285.65 ± 14.16290.20 ± 19.58
 Outer inferior258.75 ± 13.50260.79 ± 20.32258.85 ± 13.69259.62 ± 17.67258.43 ± 13.45263.23 ± 20.12
 Image quality47.60 ± 6.9448.68 ± 6.4047.76 ± 7.0147.55 ± 6.2648.53 ± 6.3641.63 ± 7.70
Macular multilayer
 GCL+64.32 ± 4.8564.47 ± 4.5464.36 ± 4.7964.22 ± 4.9464.42 ± 4.6063.68 ± 6.25
 RNFL38.02 ± 4.3939.62 ± 4.9638.06 ± 4.4239.93 ± 4.7438.17 ± 4.3738.41 ± 5.31
 Image quality47.06 ± 6.9450.04 ± 5.9547.19 ± 7.0248.48 ± 6.1747.62 ± 6.8245.80 ± 7.33
  1. Data were expressed as mean ± standard deviation. OCT retinal measurements were expressed as thickness (μm) except for image quality
  2. Abbreviations: amyloid-β, FBB florbetaben, ETDRS Early Treatment Diabetic Retinopathy Study, GCL ganglion cell layer, MCI mild cognitive impairment, PET positron emission tomography, RNFL retinal nerve fiber layer, SCD subjective cognitive decline, SUVR standardized uptake value ratio, v0 baseline visit, v2 follow-up visit at 2 years