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Table 1 Demographic characteristics of the study cohort

From: Association between retinal thickness and β-amyloid brain accumulation in individuals with subjective cognitive decline: Fundació ACE Healthy Brain Initiative

 

PET status at v0

PET status at v2

Clinical status at v2

Aβ−

Aβ+

p

Aβ−

Aβ+

p

SCD

MCI

p

n

114

15

N/A

107

22

N/A

114

15

N/A

Age

64.22 ± 7.41

68.49 ± 4.76

0.03*

65.70 ± 7.29

70.82 ± 5.48

0.002*

65.76 ± 6.77

72.73. ± 8.12

< 0.001*

Females (%)

71 (62.3%)

10 (66.7%)

0.74

68 (63.55%)

13 (59.1%)

0.69

72 (63.16%)

9 (60%)

0.85

Years of education

12.58 ± 3.94

11.80 ± 3.99

0.48

12.56 ± 3.91

12.14 ± 4.16

0.65

12.80 ± 3.86

10.07 ± 3.83

0.01*

MMSE

29.32 ± 0.90

29.53 ± 0.74

0.39

29.22 ± 1.03

29.11 ± 1.32

0.72

29.33 ± 0.88

28.25 ± 1.82

0.06

APOE ε4+ (%)

21 (18.4%)

11 (73.7%)

< 0.001*

21 (19.6%)

11 (50%)

0.003*

24 (21.05%)

8 (53.3%)

0.007*

  1. A T test was used to analyse differences on age, years of education and MMSE between groups. A Chi-square test was employed to analyse differences on the distribution of females and APOE genotype between groups
  2. *Statistical significance was set-up at p < 0.05
  3. Abbreviations: amyloid-β, APOE apolipoprotein E, MMSE Mini-Mental State Examination, PET positron emission tomography, MCI mild cognitive impairment, SCD subjective cognitive decline, v0 baseline visit, v2 2-year follow-up visit