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Table 1 Study population demographic characteristics, including comparisons between Aβ-PET groups

From: Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging

CharacteristicTotal sampleAβ-PET–Aβ-PET+P value
n (%)202 (100)118 (58)84 (42)
Gender male, n (%)100 (50)51 (43)49 (58)0.0340
Mean (SD) age, years73.5 (6.2)72.5 (6.2)74.8 (6.0)0.0110
APOE ε4 allele status carriage, n (%)64 (32)24 (21)40 (48)< 0.0001
Mean (SD) PACC score− 3.0 (6.8)− 0.5 (4.2)− 6.8 (8.1)< 0.0001
Median (IQR) MMSE score28 (4.0)29 (2.0)27 (4.2)0.0002
Median (IQR) CDR score0 (2.4)0 (0)0.5 (3.2)0.0002
Tracer, n (%)   0.048
 NAV/PiB90 (44)46 (23)44 (22)
 FLUTE70 (35)41 (20)29 (14)
 FBP42 (21)31 (15)11 (6)
Clinical classification, n (%)   < 0.0001
 CN140 (70)102 (51)38 (19)
 MCI33 (16)10 (5)23 (11)
 AD27 (13)4 (2)23 (11)
 FTD2 (1)2 (1)0 (0)
  1. Abbreviations: , β-amyloid; AD, Alzheimer’s disease; APOE, apolipoprotein E; CDR, Clinical Dementia Rating; CN, cognitively normal; FBP, 18F-florbetapir; FLUTE, 18F-flutemetamol; FTD, frontotemporal dementia; IQR, interquartile range; MCI, mild cognitive impairment; MMSE, Mini-Mental State Examination; NAV, 18F-NAV4694; PACC, Preclinical Alzheimer Cognitive Composite; PET, positron emission tomography; PiB, 11C-Pittsburgh compound B; SD, standard deviation