Table 1 Study population demographic characteristics, including comparisons between Aβ-PET groups
From: Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging
Characteristic | Total sample | Aβ-PET– | Aβ-PET+ | P value |
|---|---|---|---|---|
n (%) | 202 (100) | 118 (58) | 84 (42) | – |
Gender male, n (%) | 100 (50) | 51 (43) | 49 (58) | 0.0340 |
Mean (SD) age, years | 73.5 (6.2) | 72.5 (6.2) | 74.8 (6.0) | 0.0110 |
APOE ε4 allele status carriage, n (%) | 64 (32) | 24 (21) | 40 (48) | < 0.0001 |
Mean (SD) PACC score | − 3.0 (6.8) | − 0.5 (4.2) | − 6.8 (8.1) | < 0.0001 |
Median (IQR) MMSE score | 28 (4.0) | 29 (2.0) | 27 (4.2) | 0.0002 |
Median (IQR) CDR score | 0 (2.4) | 0 (0) | 0.5 (3.2) | 0.0002 |
Tracer, n (%) | 0.048 | |||
NAV/PiB | 90 (44) | 46 (23) | 44 (22) | – |
FLUTE | 70 (35) | 41 (20) | 29 (14) | – |
FBP | 42 (21) | 31 (15) | 11 (6) | – |
Clinical classification, n (%) | < 0.0001 | |||
CN | 140 (70) | 102 (51) | 38 (19) | – |
MCI | 33 (16) | 10 (5) | 23 (11) | – |
AD | 27 (13) | 4 (2) | 23 (11) | – |
FTD | 2 (1) | 2 (1) | 0 (0) | – |