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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Elecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging

Fig. 3

CSF biomarkers versus NAV/PiB SUVR for a Aβ42, threshold: 1054, b Aβ42/Aβ40 ratio, threshold: 64.0 (× 0.001) and c pTau/Aβ42 ratio,threshold: 0.018. Solid lines in plots a and b represent the non-linear relationship between CSF biomarkers and NAV/PiB SUVR. The solid line in plot c represents the linear relationship between NAV/PiB SUVR and pTau/Aβ42. Grey shaded areas represent the 95% CI around the solid line. Grey dashed lines represent thresholds for SUVR (vertical) and CSF (horizontal) biomarkers. Red symbols represent Aβ-PET+; blue symbols represent Aβ-PET–; circles represent CN participants; triangles represent participants with MCI; squares represent participants with AD. Abbreviations: , β-amyloid; Aβ42, β-amyloid (1–42); Aβ42/Aβ40, β-amyloid (1–42)/β-amyloid (1–40) ratio; AD, Alzheimer’s disease; CI, confidence interval; CN, cognitively normal; CSF, cerebrospinal fluid; MCI, mild cognitive impairment; NAV, 18F-NAV4694; PET, positron emission tomography; PiB, 11C-Pittsburgh compound B; pTau/Aβ42, phosphorylated tau (181P)/β-amyloid (1–42) ratio; SUVR, standardised uptake value ratio

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