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Table 2 Cognitive profile according to 18F-flutemetamol uptake regions

From: Clinical significance of focal ß-amyloid deposition measured by 18F-flutemetamol PET

Neuropsychological tests of cognitive domain

No-FMM uptake

Focal-FMM uptake

Diffuse-FMM uptake

No vs focal uptake

No vs diffuse uptake

Focal vs diffuse uptake

(n = 174)

Total (n = 53)

Frontal (n = 33)

Lateral temporal (n = 21)

Parietal (n = 32)

PPC (n = 32)

Striatum (n = 23)

(n = 83)

Language

 K-BNT

0.02 ± 1.17

− 0.94 ± 1.78

− 1.33 ± 1.68*

− 1.27 ± 1.93

−1.40 ± 2.00*

−1.50 ± 1.97*

−1.80 ± 2.00*

− 0.97 ± 1.50

< 0.001

< 0.001

1.000

Visuospatial

 Figure copying

− 0.12 ± 1.31

− 0.71 ± 2.19

− 1.10 ± 2.54

− 0.55 ± 2.02

−0.95 ± 2.55

− 1.37 ± 2.53

−1.53 ± 2.82

− 1.62 ± 3.76

0.324

< 0.001

0.089

Memory

 Verbal memory

− 0.46 ± 1.26

− 0.97 ± 1.26

− 1.12 ± 1.19#

− 0.97 ± 1.31#

− 1.05 ± 1.40#

− 1.32 ± 1.27*#

−1.63 ± 0.84*

−2.12 ± 1.04

0.020

< 0.001

< 0.001

 Visual memory

− 0.18 ± 1.10

− 0.83 ± 1.15

− 1.08 ± 1.06*#

− 0.68 ± 1.05#

− 0.93 ± 1.19*#

− 1.09 ± 1.21*

− 1.34 ± 1.08*

−1.77 ± 0.96

< 0.001

< 0.001

< 0.001

Frontal/executive

 COWAT

− 0.07 ± 1.10

− 0.78 ± 1.11

− 0.98 ± 1.08*

− 1.09 ± 1.02*

− 0.89 ± 1.30*

− 1.17 ± 1.04*

−1.32 ± 1.02*

− 1.09 ± 1.11

< 0.001

< 0.001

0.331

 Stroop test

− 0.06 ± 1.42

− 0.60 ± 1.63

− 0.93 ± 1.67

− 0.66 ± 1.57

− 0.91 ± 1.81

− 1.18 ± 1.66*

− 1.48 ± 1.54*

− 1.66 ± 1.77

0.080

< 0.001

< 0.001

Global

 MMSE

− 0.31 ± 1.35

− 1.13 ± 2.46

− 1.65 ± 2.80

− 1.04 ± 1.86

− 1.35 ± 2.86

− 1.85 ± 2.84

−2.24 ± 3.21

− 2.57 ± 2.98

0.039

< 0.001

< 0.001

 CDR-SB

0.80 ± 1.04

2.19 ± 2.63

2.94 ± 2.82*

2.55 ± 2.43

2.50 ± 2.87

3.17 ± 2.90*

3.52 ± 3.18*

3.10 ± 2.68

< 0.001

< 0.001

0.024

  1. Values are mean z-scores of neuropsychological tests and raw score of CDR-SB (mean ± SD)
  2. *p < 0.05 between regional Focal-FMM-uptake group and No-FMM-uptake group (after Bonferroni’s correction for 5 regions and 6 cognitive tests)
  3. #p < 0.05 between regional Focal-FMM-uptake group and Diffuse-FMM-uptake group (after Bonferroni’s correction for 5 regions and 6 cognitive tests)
  4. Abbreviations: FMM 18F-flutemetamol, COWAT The Controlled Oral Word Association Test, K-BNT Korean version-Boston Naming Test, MMSE Mini-Mental State Exam, CDR-SB Clinical Dementia Rating Scale Sum of Boxes