From: Clinical significance of focal ß-amyloid deposition measured by 18F-flutemetamol PET
Neuropsychological tests of cognitive domain | No-FMM uptake | Focal-FMM uptake | Diffuse-FMM uptake | No vs focal uptake | No vs diffuse uptake | Focal vs diffuse uptake | |||||
---|---|---|---|---|---|---|---|---|---|---|---|
(n = 174) | Total (n = 53) | Frontal (n = 33) | Lateral temporal (n = 21) | Parietal (n = 32) | PPC (n = 32) | Striatum (n = 23) | (n = 83) | ||||
Language | |||||||||||
K-BNT | 0.02 ± 1.17 | − 0.94 ± 1.78 | − 1.33 ± 1.68* | − 1.27 ± 1.93 | −1.40 ± 2.00* | −1.50 ± 1.97* | −1.80 ± 2.00* | − 0.97 ± 1.50 | < 0.001 | < 0.001 | 1.000 |
Visuospatial | |||||||||||
Figure copying | − 0.12 ± 1.31 | − 0.71 ± 2.19 | − 1.10 ± 2.54 | − 0.55 ± 2.02 | −0.95 ± 2.55 | − 1.37 ± 2.53 | −1.53 ± 2.82 | − 1.62 ± 3.76 | 0.324 | < 0.001 | 0.089 |
Memory | |||||||||||
Verbal memory | − 0.46 ± 1.26 | − 0.97 ± 1.26 | − 1.12 ± 1.19# | − 0.97 ± 1.31# | − 1.05 ± 1.40# | − 1.32 ± 1.27*# | −1.63 ± 0.84* | −2.12 ± 1.04 | 0.020 | < 0.001 | < 0.001 |
Visual memory | − 0.18 ± 1.10 | − 0.83 ± 1.15 | − 1.08 ± 1.06*# | − 0.68 ± 1.05# | − 0.93 ± 1.19*# | − 1.09 ± 1.21* | − 1.34 ± 1.08* | −1.77 ± 0.96 | < 0.001 | < 0.001 | < 0.001 |
Frontal/executive | |||||||||||
COWAT | − 0.07 ± 1.10 | − 0.78 ± 1.11 | − 0.98 ± 1.08* | − 1.09 ± 1.02* | − 0.89 ± 1.30* | − 1.17 ± 1.04* | −1.32 ± 1.02* | − 1.09 ± 1.11 | < 0.001 | < 0.001 | 0.331 |
Stroop test | − 0.06 ± 1.42 | − 0.60 ± 1.63 | − 0.93 ± 1.67 | − 0.66 ± 1.57 | − 0.91 ± 1.81 | − 1.18 ± 1.66* | − 1.48 ± 1.54* | − 1.66 ± 1.77 | 0.080 | < 0.001 | < 0.001 |
Global | |||||||||||
MMSE | − 0.31 ± 1.35 | − 1.13 ± 2.46 | − 1.65 ± 2.80 | − 1.04 ± 1.86 | − 1.35 ± 2.86 | − 1.85 ± 2.84 | −2.24 ± 3.21 | − 2.57 ± 2.98 | 0.039 | < 0.001 | < 0.001 |
CDR-SB | 0.80 ± 1.04 | 2.19 ± 2.63 | 2.94 ± 2.82* | 2.55 ± 2.43 | 2.50 ± 2.87 | 3.17 ± 2.90* | 3.52 ± 3.18* | 3.10 ± 2.68 | < 0.001 | < 0.001 | 0.024 |