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Table 2 Cognitive profile according to 18F-flutemetamol uptake regions

From: Clinical significance of focal ß-amyloid deposition measured by 18F-flutemetamol PET

Neuropsychological tests of cognitive domainNo-FMM uptakeFocal-FMM uptakeDiffuse-FMM uptakeNo vs focal uptakeNo vs diffuse uptakeFocal vs diffuse uptake
(n = 174)Total (n = 53)Frontal (n = 33)Lateral temporal (n = 21)Parietal (n = 32)PPC (n = 32)Striatum (n = 23)(n = 83)
Language
 K-BNT0.02 ± 1.17− 0.94 ± 1.78− 1.33 ± 1.68*− 1.27 ± 1.93−1.40 ± 2.00*−1.50 ± 1.97*−1.80 ± 2.00*− 0.97 ± 1.50< 0.001< 0.0011.000
Visuospatial
 Figure copying− 0.12 ± 1.31− 0.71 ± 2.19− 1.10 ± 2.54− 0.55 ± 2.02−0.95 ± 2.55− 1.37 ± 2.53−1.53 ± 2.82− 1.62 ± 3.760.324< 0.0010.089
Memory
 Verbal memory− 0.46 ± 1.26− 0.97 ± 1.26− 1.12 ± 1.19#− 0.97 ± 1.31#− 1.05 ± 1.40#− 1.32 ± 1.27*#−1.63 ± 0.84*−2.12 ± 1.040.020< 0.001< 0.001
 Visual memory− 0.18 ± 1.10− 0.83 ± 1.15− 1.08 ± 1.06*#− 0.68 ± 1.05#− 0.93 ± 1.19*#− 1.09 ± 1.21*− 1.34 ± 1.08*−1.77 ± 0.96< 0.001< 0.001< 0.001
Frontal/executive
 COWAT− 0.07 ± 1.10− 0.78 ± 1.11− 0.98 ± 1.08*− 1.09 ± 1.02*− 0.89 ± 1.30*− 1.17 ± 1.04*−1.32 ± 1.02*− 1.09 ± 1.11< 0.001< 0.0010.331
 Stroop test− 0.06 ± 1.42− 0.60 ± 1.63− 0.93 ± 1.67− 0.66 ± 1.57− 0.91 ± 1.81− 1.18 ± 1.66*− 1.48 ± 1.54*− 1.66 ± 1.770.080< 0.001< 0.001
Global
 MMSE− 0.31 ± 1.35− 1.13 ± 2.46− 1.65 ± 2.80− 1.04 ± 1.86− 1.35 ± 2.86− 1.85 ± 2.84−2.24 ± 3.21− 2.57 ± 2.980.039< 0.001< 0.001
 CDR-SB0.80 ± 1.042.19 ± 2.632.94 ± 2.82*2.55 ± 2.432.50 ± 2.873.17 ± 2.90*3.52 ± 3.18*3.10 ± 2.68< 0.001< 0.0010.024
  1. Values are mean z-scores of neuropsychological tests and raw score of CDR-SB (mean ± SD)
  2. *p < 0.05 between regional Focal-FMM-uptake group and No-FMM-uptake group (after Bonferroni’s correction for 5 regions and 6 cognitive tests)
  3. #p < 0.05 between regional Focal-FMM-uptake group and Diffuse-FMM-uptake group (after Bonferroni’s correction for 5 regions and 6 cognitive tests)
  4. Abbreviations: FMM 18F-flutemetamol, COWAT The Controlled Oral Word Association Test, K-BNT Korean version-Boston Naming Test, MMSE Mini-Mental State Exam, CDR-SB Clinical Dementia Rating Scale Sum of Boxes