Sample size | Total | Â | Toulouse Registry | ALFA Study | Generation Scotland | pilotHO.nl | ||||
---|---|---|---|---|---|---|---|---|---|---|
n = 2595 | n = 324 | n = 158 | n = 64 | n = 271 | n = 124 | n = 1947 | n = 61 | n = 220 | n = 75 | |
Outcome | Enrolment* | CSF Aβ +ve^ | Enrolment* | CSF Aβ +ve^ | Enrolment* | CSF Aβ +ve^ | Enrolment* | CSF Aβ +ve^ | Enrolment* | CSF Aβ +ve^ |
Aged over 70 years Old | 0.97 (0.95–0.99) | 1.06 (1.02–1.10) | 0.99 (0.94–1.03) | 1.10 (1.01–1.20) | 0.99 (0.95–1.03) | 1.01 (0.94–1.08) | 0.97 (0.93–1.01) | 1.23 (1.08–1.45) | 0.96 (0.93–1.00) | 1.03 (0.97–1.11) |
Male | 1.56 (1.19–2.04) | 1.28 (0.81–2.04) | 1.17 (0.58–2.42) | 0.30 (0.08–0.96) | 2.03 (1.24–3.35) | 2.03 (0.92–4.60) | 1.81 (1.11–3.01) | 1.35 (0.47–4.08) | 1.13 (0.66–1.94) | 2.01 (0.77–5.36) |
Highly educated | 1.64 (1.23–2.17) | 0.89 (0.56–1.42) | 1.44 (0.69–2.98) | 0.72 (0.25–2.13) | 1.42 (0.87–2.31) | 1.10 (0.50–2.39) | 2.20 (1.34–3.59) | 0.66 (0.22–1.88) | 1.33 (0.67–2.67) | 0.75 (0.24–2.51) |
APOE ɛ4 genotype | 0.95 (0.70–1.28) | 2.99 (1.81–4.94) | NA | 6.42 (1.93–24.1) | 0.68 (0.41–1.10) | 1.72 (0.79–3.86) | 1.37 (0.84–2.25) | 7.20 (2.2–28.77) | 0.92 (0.49–1.72) | 3.34 (1.22–9.48) |
Family history of Dementia | 1.66 (1.19–2.31) | 1.58 (0.83–3.00) | 1.04 (0.50–2.15) | 0.95 (0.31–2.98) | 1.12 (0.38–3.23) | NA# | 2.95 (1.73–4.91) | 2.90 (0.97–8.96) | 1.27 (0.73–2.22) | 1.94 (0.68–6.09) |
Subjective cognitive decline | 0.86 (0.58–1.27) | 1.51 (0.88–2.61) | 0.29 (0.09–0.76) | 2.93 (0.67–20.6) | 0.79 (0.41–1.55) | 1.15 (0.38–3.22) | NA | NA | 1.16 (0.62–2.15) | 1.73 (0.62–4.79) |
Low memory score | 0.84 (0.60–1.17) | 1.47 (0.82–2.61) | 0.63 (0.21–1.87) | 18.90 (2.87–377) | 0.95 (0.56–1.64) | 1.29 (0.55–2.96) | 0.78 (0.44–1.31) | 0.95 (0.28–3.02) | 0.91 (0.29–2.83) | 0.58 (0.03–4.98) |