Skip to main content

Advertisement

Springer Nature is making SARS-CoV-2 and COVID-19 research free. View research | View latest news | Sign up for updates

Table 4 Univariate logistic regression for enrolment and CSF Aβ1–42 positivity in whole sample and stratified by recruitment setting

From: Prescreening for European Prevention of Alzheimer Dementia (EPAD) trial-ready cohort: impact of AD risk factors and recruitment settings

Sample sizeTotal Toulouse RegistryALFA StudyGeneration ScotlandpilotHO.nl
n = 2595n = 324n = 158n = 64n = 271n = 124n = 1947n = 61n = 220n = 75
OutcomeEnrolment*CSF Aβ +ve^Enrolment*CSF Aβ +ve^Enrolment*CSF Aβ +ve^Enrolment*CSF Aβ +ve^Enrolment*CSF Aβ +ve^
Aged over 70 years Old0.97 (0.95–0.99)1.06 (1.02–1.10)0.99 (0.94–1.03)1.10 (1.01–1.20)0.99 (0.95–1.03)1.01 (0.94–1.08)0.97 (0.93–1.01)1.23 (1.08–1.45)0.96 (0.93–1.00)1.03 (0.97–1.11)
Male1.56 (1.19–2.04)1.28 (0.81–2.04)1.17 (0.58–2.42)0.30 (0.08–0.96)2.03 (1.24–3.35)2.03 (0.92–4.60)1.81 (1.11–3.01)1.35 (0.47–4.08)1.13 (0.66–1.94)2.01 (0.77–5.36)
Highly educated1.64 (1.23–2.17)0.89 (0.56–1.42)1.44 (0.69–2.98)0.72 (0.25–2.13)1.42 (0.87–2.31)1.10 (0.50–2.39)2.20 (1.34–3.59)0.66 (0.22–1.88)1.33 (0.67–2.67)0.75 (0.24–2.51)
APOE ɛ4 genotype0.95 (0.70–1.28)2.99 (1.81–4.94)NA6.42 (1.93–24.1)0.68 (0.41–1.10)1.72 (0.79–3.86)1.37 (0.84–2.25)7.20 (2.2–28.77)0.92 (0.49–1.72)3.34 (1.22–9.48)
Family history of Dementia1.66 (1.19–2.31)1.58 (0.83–3.00)1.04 (0.50–2.15)0.95 (0.31–2.98)1.12 (0.38–3.23)NA#2.95 (1.73–4.91)2.90 (0.97–8.96)1.27 (0.73–2.22)1.94 (0.68–6.09)
Subjective cognitive decline0.86 (0.58–1.27)1.51 (0.88–2.61)0.29 (0.09–0.76)2.93 (0.67–20.6)0.79 (0.41–1.55)1.15 (0.38–3.22)NANA1.16 (0.62–2.15)1.73 (0.62–4.79)
Low memory score0.84 (0.60–1.17)1.47 (0.82–2.61)0.63 (0.21–1.87)18.90 (2.87–377)0.95 (0.56–1.64)1.29 (0.55–2.96)0.78 (0.44–1.31)0.95 (0.28–3.02)0.91 (0.29–2.83)0.58 (0.03–4.98)
  1. Odds ratio (95% CI); CSF cerebrospinal fluid. Italics is significant p < 0.05. *Odds ratio for participating baseline/screening visit after invitation. ^Odds ratio for amyloid positivity among those included in EPAD-LCS. #Infinite, not possible to calculate a value