Changes in gray matter volume and functional connectivity in dementia with Lewy bodies compared to Alzheimer’s disease and normal aging: implications for fluctuations

Table 1 Demographics and fluctuation scores of the cohorts

A	HC (n = 22)	DLB (n = 92)	AD (n = 70)	Between-group differences
Gender (m/f)	11/11	39/40	26/32	χ² = 0.42, p = 0.81
Age	66.5 ± 7.8	70.1 ± 9.4	74.4 ± 8.3	AD vs HC: p = 0.0010 AD vs DLB: p = 0.0084 DLB vs HC: NS
MMSE	28.9 ± 0.9	25.6 ± 4.0	23.8 ± 3.8	DLB vs HC: p = 0.0001 AD vs HC: p < 0.0001 DLB vs AD: NS
MCFS	0.3 ± 0.6	1.9 ± 1.2	0.7 ± 1.0	DLB vs HC: p < 0.0001 DLB vs AD: p < 0.0001 AD vs HC: NS
B	HC (n = 22)	DLB (n = 79)	AD (n = 58)	Between-group differences
Gender (m/f)	11/11	39/40	26/32	χ² = 0.33, p = 0.85
Age	66.5 ± 7.8	70.3 ± 9.5	73.7 ± 8.3	AD vs HC: p = 0.0045 DLB vs HC: NS DLB vs AD: NS
MMSE	28.9 ± 0.9	25.8 ± 3.8	24.4 ± 3.2	DLB vs HC: p = 0.0002 AD vs HC: p < 0.0001 DLB vs AD: NS
MCFS	0.3 ± 0.6	1.8 ± 1.2	0.6 ± 0.9	DLB vs HC: p < 0.0001 DLB vs AD: p < 0.0001 AD vs HC: NS

(A) Cohort of the voxel-based morphometry analysis. (B) Cohort of the functional connectivity analysis. Data are presented as mean ± SD except where noted. Abbreviations: AD Alzheimer’s disease, DLB dementia with Lewy bodies, HC healthy controls, f female, m male, MCFS Mayo Clinic Fluctuation Scale, MMSE Mini-Mental State Examination, NS non-significant

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