Skip to main content
Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Focused ultrasound-induced blood-brain barrier opening improves adult hippocampal neurogenesis and cognitive function in a cholinergic degeneration dementia rat model

Fig. 6

FUS improves cognitive function and spatial memory. a Learning curves of 5 consecutive days. Latency indicates the time required for the rat to find the escape platform during training trials. During the 5 days of training, the time to find the platform for rats in the control, SAP, and SAP+FUS groups gradually decreased. b In the probe test, rats in the SAP+FUS group crossed the platform area a significantly higher number of times (c) and spent a significantly longer time in the platform zone than did rats in the SAP or control groups. d Though rats in the SAP+FUS group had a longer time spent in the target quadrant zone, there were no significant differences among the groups. e No significant differences were found in the swim speed among the groups. f Trajectories of rats in the Morris water maze tests in the control group, SAP group, and SAP+FUS group. Data are expressed as mean ± SE. n = 8 for each group. *P < 0.05, **P < 0.01; one-way and two-way ANOVA with Tukey’s multiple comparisons test

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193