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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: Focused ultrasound-induced blood-brain barrier opening improves adult hippocampal neurogenesis and cognitive function in a cholinergic degeneration dementia rat model

Fig. 1

Schematic of the experimental procedure and FUS system. a Timeline of the focused ultrasound (FUS) experiment for the analysis of AChE activity and BDNF expression 24 h after sonication (control, n = 4; 192 IgG-saporin [SAP], n = 4; SAP+FUS, n = 4). b BrdU and doublecortin (DCX) 5 days after sonication (control, n = 4; SAP, n = 4; SAP+FUS, n = 4). c AChE, BDNF, BrdU/NeuN, and BrdU/GFAP 18 days after sonication (control, n = 8; SAP, n = 8; SAP+FUS, n = 8). d Confirmed FUS-mediated blood-brain barrier (BBB) opening with MRI. Gadolinium-enhanced T1-weighted images show contrast enhancement. Arrow indicates regions of BBB opening. e Confirmed FUS-mediated edema with T2-weighted MRI

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Alzheimer's Research & Therapy

ISSN: 1758-9193