Fig. 5
Overall receiver operating characteristics (ROC) curves for aMCI subgroups calculated in multivariate logistic models. The area under the curve (AUC) was significantly improved in combined biomarkers compared with single biomarkers (P = 0.014 for APOE ε4 alone vs APOE ε4 + plasma Aβ1–42, P = 0.002 for APOE ε4 alone vs APOE ε4 + APOE ε2 + plasma Aβ1–42, P = 0.002 for plasma Aβ1–42 vs APOE ε4 + plasma Aβ1–42, and P < 0.001 for APOE ε4 + APOE ε2 + plasma Aβ1–42). Abbreviations: Aβ, Amyloid β; AUC, area under the curve; ROC, receiver operating characteristics