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Table 3 Amyloid-adjusted predictive value of patient features for amyloid status based on PET or CSF

From: PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases

   Total SCD MCI Dementia
      Imputed     Imputed     Imputed     Imputed
Predictor Outcome Odds ratio
(95% CI)
punc pFDR Odds ratio
(95% CI)
pFDR Odds ratio
(95% CI)
punc pFDR Odds ratio
(95% CI)
pFDR Odds ratio punc pFDR Odds ratio
(95% CI)
pFDR Odds ratio punc pFDR Odds ratio
(95% CI)
pFDR
Age PET 1.03 (1.00, 1.06)    1.03 (1.00, 1.06)   1.04 (0.99, 1.10)    1.04 (0.99, 1.1)   0.97 (0.91, 1.04)    0.97 (0.91, 1.04)       
CSF 0.99 (0.96, 1.02)    0.99 (0.96, 1.02)   1.02 (0.97, 1.07)    1.02 (0.97, 1.07)   0.98 (0.92, 1.04)    0.98 (0.92, 1.04)       
Sex, F PET       1.17 (0.49, 2.77)    1.17 (0.49, 2.77)   2.27 (0.75, 6.90)    2.27 (0.75, 6.90)   1.93 (1.04, 3.58) *   1.93 (1.04, 3.58)  
CSF       1.76 (0.80, 3.90)    1.76 (0.8, 3.9)   1.11 (0.37, 3.35)    1.11 (0.37, 3.35)   0.84 (0.44, 1.59)    0.84 (0.44, 1.59)  
Education PET 1.06 (0.89, 1.27)    1.07 (0.89, 1.27)             1.16 (0.9, 1.49)    1.18 (0.92, 1.51)  
CSF 1.00 (0.84, 1.19)    1.00 (0.84, 1.19)             1.15 (0.89, 1.50)    1.14 (0.88, 1.48)  
APOE E4 PET 2.58 (1.65, 4.03) *** *** 2.52 (1.62, 3.93) *** 1.54 (0.62, 3.78)    1.56 (0.63, 3.82)   9.44 (2.93, 30.39) *** ** 8.79 (2.72, 28.41) ** 2.22 (1.20, 4.09) * * 2.14 (1.16, 3.95) *
CSF 2.30 (1.47, 3.60) *** ** 2.28 (1.45, 3.57) ** 3.07 (1.33, 7.07) **   3.01 (1.3, 6.94)   1.85 (0.58, 5.92)    1.85 (0.58, 5.88)   2.00 (1.06, 3.78) *   2.00 (1.07, 3.75)  
CSF tau PET 1.003 (1.003, 1.004) *** *** 1.003 (1.003, 1.004) *** 1.003 (1.001, 1.005) ** * 1.003 (1.001, 1.005) * 1.008 (1.004, 1.012) *** *** 1.008 (1.004, 1.012) ** 1.003 (1.002, 1.004) *** *** 1.003 (1.002, 1.004) ***
CSF 1.001 (1.000, 1.002) ** * 1.001 (1.000, 1.002) * 1.002 (1.000, 1.003)    1.001 (1.000, 1.003)   0.999 (0.997, 1.001)    0.999 (0.997, 1.001)   1.001 (1.000, 1.002)    1.001 (1.000, 1.002)  
CSF p-tau PET 1.04 (1.03, 1.05) *** *** 1.04 (1.03, 1.05) *** 1.02 (1.01, 1.04) ** * 1.03 (1.01, 1.04) * 1.05 (1.02, 1.07) *** ** 1.05 (1.02, 1.07) ** 1.04 (1.03, 1.05) *** *** 1.04 (1.03, 1.05) ***
CSF 1.01 (1.00, 1.02) *   1.01 (1.00, 1.02)   1.01 (1.00, 1.03)    1.01 (0.99, 1.02)   0.99 (0.98, 1.01)    0.99 (0.98, 1.01)   1.01 (1.00, 1.02)    1.01 (1.00, 1.02)  
MMSE PET 1.11 (1.05, 1.17) *** ** 1.10 (1.04, 1.17) ** 0.93 (0.80, 1.10)    0.93 (0.79, 1.09)            
CSF 1.10 (1.04, 1.16) ** ** 1.10 (1.04, 1.16) ** 1.21 (1.03, 1.41) *   1.19 (1.02, 1.38)            
Memory PET 1.22 (1.12, 1.34) *** *** 1.22 (1.12, 1.33) *** 0.99 (0.69, 1.42)    1.01 (0.7, 1.46)   1.25 (0.96, 1.64)    1.27 (0.97, 1.65)   1.18 (1.05, 1.32) ** * 1.17 (1.05, 1.31) *
CSF 1.09 (1.00, 1.19) *   1.09 (1.01, 1.19)   1.23 (0.87, 1.75)    1.21 (0.85, 1.72)   0.96 (0.71, 1.30)    0.92 (0.68, 1.25)   1.00 (0.89, 1.11)    1.01 (0.91, 1.12)  
Language PET            0.23 (0.08, 0.68) ** * 0.32 (0.10, 1.01)       
CSF            1.59 (0.77, 3.27)    1.37 (0.63, 2.98)       
Executive PET       0.99 (0.67, 1.48)    0.99 (0.67, 1.47)   0.61 (0.33, 1.12)    0.62 (0.34, 1.14)   1.11 (0.88, 1.40)    1.10 (0.87, 1.39)  
CSF       1.05 (0.71, 1.55)    1.05 (0.72, 1.54)   1.18 (0.64, 2.17)    1.17 (0.64, 2.15)   0.81 (0.64, 1.03)    0.82 (0.64, 1.04)  
Visuospatial PET 1.19 (1.03, 1.37) * * 1.17 (1.03, 1.34) * 0.77 (0.49, 1.22)    0.73 (0.46, 1.18)        1.32 (1.10, 1.59) ** * 1.28 (1.07, 1.53) *
CSF 1.20 (1.04, 1.39) * * 1.16 (1.01, 1.34)   1.53 (0.99, 2.38)    1.58 (1.01, 2.45)        0.99 (0.84, 1.17)    0.97 (0.83, 1.13)  
MRI MTA PET            0.55 (0.28, 1.05)    0.58 (0.30, 1.09)       
CSF            1.78 (0.87, 3.63)    1.52 (0.76, 3.03)       
MRI PCA PET            1.09 (0.48, 2.46)    1.11 (0.50, 2.48)       
CSF            0.69 (0.30, 1.58)    0.69 (0.31, 1.52)       
MRI Fazekas PET       0.76 (0.36, 1.62)    0.7 (0.33, 1.5)            
CSF       1.56 (0.83, 2.96)    1.48 (0.78, 2.78)            
MRI
microbleeds
PET 2.08 (1.07, 4.03) *   1.75 (0.90, 3.41)   2.15 (0.60, 7.67)    1.94 (0.55, 6.86)   1.62 (0.43, 6.12)    1.30 (0.36, 4.68)       
CSF 0.89 (0.46, 1.73)    0.88 (0.46, 1.71)   1.01 (0.29, 3.57)    0.91 (0.26, 3.17)   0.75 (0.20, 2.81)    0.81 (0.22, 2.94)       
  1. ***p < 0.001, **p < 0.01, *p < 0.05. p values indicate the significance of the patient feature in the model. Uncorrected p values and corrected p values are reported per model, additionally corrected p values for imputed data. False discovery rate (FDR) correction was performed for multiple comparisons. Cognitive scores have been multiplied by −1; therefore, lower scores usually indicate higher odds ratios for amyloid positivity