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Table 3 Amyloid-adjusted predictive value of patient features for amyloid status based on PET or CSF

From: PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases

  

Total

SCD

MCI

Dementia

     

Imputed

   

Imputed

   

Imputed

   

Imputed

Predictor

Outcome

Odds ratio

(95% CI)

punc

pFDR

Odds ratio

(95% CI)

pFDR

Odds ratio

(95% CI)

punc

pFDR

Odds ratio

(95% CI)

pFDR

Odds ratio

punc

pFDR

Odds ratio

(95% CI)

pFDR

Odds ratio

punc

pFDR

Odds ratio

(95% CI)

pFDR

Age

PET

1.03 (1.00, 1.06)

  

1.03 (1.00, 1.06)

 

1.04 (0.99, 1.10)

  

1.04 (0.99, 1.1)

 

0.97 (0.91, 1.04)

  

0.97 (0.91, 1.04)

      

CSF

0.99 (0.96, 1.02)

  

0.99 (0.96, 1.02)

 

1.02 (0.97, 1.07)

  

1.02 (0.97, 1.07)

 

0.98 (0.92, 1.04)

  

0.98 (0.92, 1.04)

      

Sex, F

PET

     

1.17 (0.49, 2.77)

  

1.17 (0.49, 2.77)

 

2.27 (0.75, 6.90)

  

2.27 (0.75, 6.90)

 

1.93 (1.04, 3.58)

*

 

1.93 (1.04, 3.58)

 

CSF

     

1.76 (0.80, 3.90)

  

1.76 (0.8, 3.9)

 

1.11 (0.37, 3.35)

  

1.11 (0.37, 3.35)

 

0.84 (0.44, 1.59)

  

0.84 (0.44, 1.59)

 

Education

PET

1.06 (0.89, 1.27)

  

1.07 (0.89, 1.27)

           

1.16 (0.9, 1.49)

  

1.18 (0.92, 1.51)

 

CSF

1.00 (0.84, 1.19)

  

1.00 (0.84, 1.19)

           

1.15 (0.89, 1.50)

  

1.14 (0.88, 1.48)

 

APOE E4

PET

2.58 (1.65, 4.03)

***

***

2.52 (1.62, 3.93)

***

1.54 (0.62, 3.78)

  

1.56 (0.63, 3.82)

 

9.44 (2.93, 30.39)

***

**

8.79 (2.72, 28.41)

**

2.22 (1.20, 4.09)

*

*

2.14 (1.16, 3.95)

*

CSF

2.30 (1.47, 3.60)

***

**

2.28 (1.45, 3.57)

**

3.07 (1.33, 7.07)

**

 

3.01 (1.3, 6.94)

 

1.85 (0.58, 5.92)

  

1.85 (0.58, 5.88)

 

2.00 (1.06, 3.78)

*

 

2.00 (1.07, 3.75)

 

CSF tau

PET

1.003 (1.003, 1.004)

***

***

1.003 (1.003, 1.004)

***

1.003 (1.001, 1.005)

**

*

1.003 (1.001, 1.005)

*

1.008 (1.004, 1.012)

***

***

1.008 (1.004, 1.012)

**

1.003 (1.002, 1.004)

***

***

1.003 (1.002, 1.004)

***

CSF

1.001 (1.000, 1.002)

**

*

1.001 (1.000, 1.002)

*

1.002 (1.000, 1.003)

  

1.001 (1.000, 1.003)

 

0.999 (0.997, 1.001)

  

0.999 (0.997, 1.001)

 

1.001 (1.000, 1.002)

  

1.001 (1.000, 1.002)

 

CSF p-tau

PET

1.04 (1.03, 1.05)

***

***

1.04 (1.03, 1.05)

***

1.02 (1.01, 1.04)

**

*

1.03 (1.01, 1.04)

*

1.05 (1.02, 1.07)

***

**

1.05 (1.02, 1.07)

**

1.04 (1.03, 1.05)

***

***

1.04 (1.03, 1.05)

***

CSF

1.01 (1.00, 1.02)

*

 

1.01 (1.00, 1.02)

 

1.01 (1.00, 1.03)

  

1.01 (0.99, 1.02)

 

0.99 (0.98, 1.01)

  

0.99 (0.98, 1.01)

 

1.01 (1.00, 1.02)

  

1.01 (1.00, 1.02)

 

MMSE

PET

1.11 (1.05, 1.17)

***

**

1.10 (1.04, 1.17)

**

0.93 (0.80, 1.10)

  

0.93 (0.79, 1.09)

           

CSF

1.10 (1.04, 1.16)

**

**

1.10 (1.04, 1.16)

**

1.21 (1.03, 1.41)

*

 

1.19 (1.02, 1.38)

           

Memory

PET

1.22 (1.12, 1.34)

***

***

1.22 (1.12, 1.33)

***

0.99 (0.69, 1.42)

  

1.01 (0.7, 1.46)

 

1.25 (0.96, 1.64)

  

1.27 (0.97, 1.65)

 

1.18 (1.05, 1.32)

**

*

1.17 (1.05, 1.31)

*

CSF

1.09 (1.00, 1.19)

*

 

1.09 (1.01, 1.19)

 

1.23 (0.87, 1.75)

  

1.21 (0.85, 1.72)

 

0.96 (0.71, 1.30)

  

0.92 (0.68, 1.25)

 

1.00 (0.89, 1.11)

  

1.01 (0.91, 1.12)

 

Language

PET

          

0.23 (0.08, 0.68)

**

*

0.32 (0.10, 1.01)

      

CSF

          

1.59 (0.77, 3.27)

  

1.37 (0.63, 2.98)

      

Executive

PET

     

0.99 (0.67, 1.48)

  

0.99 (0.67, 1.47)

 

0.61 (0.33, 1.12)

  

0.62 (0.34, 1.14)

 

1.11 (0.88, 1.40)

  

1.10 (0.87, 1.39)

 

CSF

     

1.05 (0.71, 1.55)

  

1.05 (0.72, 1.54)

 

1.18 (0.64, 2.17)

  

1.17 (0.64, 2.15)

 

0.81 (0.64, 1.03)

  

0.82 (0.64, 1.04)

 

Visuospatial

PET

1.19 (1.03, 1.37)

*

*

1.17 (1.03, 1.34)

*

0.77 (0.49, 1.22)

  

0.73 (0.46, 1.18)

      

1.32 (1.10, 1.59)

**

*

1.28 (1.07, 1.53)

*

CSF

1.20 (1.04, 1.39)

*

*

1.16 (1.01, 1.34)

 

1.53 (0.99, 2.38)

  

1.58 (1.01, 2.45)

      

0.99 (0.84, 1.17)

  

0.97 (0.83, 1.13)

 

MRI MTA

PET

          

0.55 (0.28, 1.05)

  

0.58 (0.30, 1.09)

      

CSF

          

1.78 (0.87, 3.63)

  

1.52 (0.76, 3.03)

      

MRI PCA

PET

          

1.09 (0.48, 2.46)

  

1.11 (0.50, 2.48)

      

CSF

          

0.69 (0.30, 1.58)

  

0.69 (0.31, 1.52)

      

MRI Fazekas

PET

     

0.76 (0.36, 1.62)

  

0.7 (0.33, 1.5)

           

CSF

     

1.56 (0.83, 2.96)

  

1.48 (0.78, 2.78)

           

MRI

microbleeds

PET

2.08 (1.07, 4.03)

*

 

1.75 (0.90, 3.41)

 

2.15 (0.60, 7.67)

  

1.94 (0.55, 6.86)

 

1.62 (0.43, 6.12)

  

1.30 (0.36, 4.68)

      

CSF

0.89 (0.46, 1.73)

  

0.88 (0.46, 1.71)

 

1.01 (0.29, 3.57)

  

0.91 (0.26, 3.17)

 

0.75 (0.20, 2.81)

  

0.81 (0.22, 2.94)

      
  1. ***p < 0.001, **p < 0.01, *p < 0.05. p values indicate the significance of the patient feature in the model. Uncorrected p values and corrected p values are reported per model, additionally corrected p values for imputed data. False discovery rate (FDR) correction was performed for multiple comparisons. Cognitive scores have been multiplied by −1; therefore, lower scores usually indicate higher odds ratios for amyloid positivity
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Alzheimer's Research & Therapy

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