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Table 2 Predictive value of patient features for amyloid status based on PET or CSF

From: PET and CSF amyloid-β status are differently predicted by patient features: information from discordant cases

  TotalSCDMCIDementia
     Imputed   Imputed   Imputed   Imputed
PredictorOutcomeOdds ratio
(95% CI)
puncpFDROdds ratio
(95% CI)
pFDROdds ratio
(95% CI)
puncpFDROdds ratio
(95% CI)
pFDROdds ratio
(95% CI)
puncpFDROdds ratio
(95% CI)
pFDROdds ratio
(95% CI)
puncpFDROdds ratio
(95% CI)
pFDR
AgePET1.02 (1.00, 1.04)  1.02 (1.00, 1.04) 1.06 (1.01, 1.12)* 1.06 (1.01, 1.12) 0.96 (0.92, 1.00)  0.96 (0.92, 1.00)      
CSF1.01 (0.99, 1.03)  1.01 (0.99, 1.03) 1.04 (1.00, 1.09)  1.04 (1.00, 1.09) 0.96 (0.92, 1.00)  0.96 (0.92, 1.00)      
Sex, FPET     1.64 (0.81, 3.36)  1.64 (0.81, 3.36) 2.45 (1.14, 5.26)* 2.45 (1.14, 5.26) 1.70 (1.13, 2.53)***1.70 (1.13, 2.53)*
CSF     1.91 (0.99, 3.69)  1.91 (0.99, 3.69) 2.01 (0.94, 4.28)  2.01 (0.94, 4.28) 1.40 (0.93, 2.12)  1.40 (0.93, 2.12) 
EducationPET1.06 (0.94, 1.19)  1.07 (0.95, 1.20)           1.28 (1.08, 1.52)****1.30 (1.10, 1.53)**
CSF1.04 (0.93, 1.17)  1.05 (0.94, 1.18)           1.29 (1.08, 1.54)****1.30 (1.09, 1.54)**
APOE E4PET4.72 (3.46, 6.44)******4.57 (3.34, 6.24)***2.97 (1.42, 6.20)***2.97 (1.42, 6.19)*14.55 (6.08, 34.82)******13.43 (5.62, 32.11)***3.63 (2.39, 5.50)******3.51 (2.30, 5.34)***
CSF4.60 (3.36, 6.28)******4.46 (3.26, 6.12)***3.82 (1.90, 7.70)******3.75 (1.86, 7.57)**8.28 (3.70, 18.54)******7.76 (3.49, 17.27)***3.68 (2.39, 5.69)******3.59 (2.33, 5.53)***
CSF tauPET1.005 (1.004, 1.006)******1.005 (1.004, 1.006)***1.004 (1.002, 1.006)******1.004 (1.002, 1.006)***1.008 (1.005, 1.011)******1.008 (1.005, 1.011)***1.004 (1.003, 1.005)******1.004 (1.003, 1.005)***
CSF1.004 (1.003, 1.005)******1.004 (1.003, 1.005)***1.003 (1.002, 1.005)******1.003 (1.002, 1.005)**1.003 (1.002, 1.005)******1.003 (1.002, 1.005)***1.004 (1.003, 1.004)******1.003 (1.002, 1.004)***
CSF p-tauPET1.05 (1.04, 1.06)******1.05 (1.04, 1.06)***1.04 (1.02, 1.05)******1.04 (1.02, 1.05)***1.05 (1.03, 1.07)******1.05 (1.03, 1.07)***1.05 (1.04, 1.06)******1.05 (1.04, 1.06)***
CSF1.04 (1.03, 1.04)******1.04 (1.03, 1.04)***1.03 (1.01, 1.04)******1.02 (1.01, 1.04)**1.03 (1.01, 1.04)******1.03 (1.01, 1.04)***1.04 (1.03, 1.05)******1.04 (1.03, 1.05)***
MMSEPET1.20 (1.15, 1.25)******1.19 (1.14, 1.24)***1.03 (0.89, 1.19)  1.02 (0.88, 1.18)           
CSF1.20 (1.15, 1.25)******1.19 (1.14, 1.25)***1.15 (1.01, 1.31)* 1.13 (1.00, 1.29)           
MemoryPET1.36 (1.27, 1.47)******1.36 (1.27, 1.46)***1.13 (0.82, 1.55)  1.14 (0.83, 1.56) 1.26 (1.02, 1.57)* 1.25 (1.00, 1.54) 1.20 (1.10, 1.30)******1.20 (1.10, 1.31)***
CSF1.32 (1.23, 1.42)******1.32 (1.23, 1.42)***1.23 (0.92, 1.64)  1.22 (0.91, 1.62) 1.16 (0.95, 1.42)  1.12 (0.92, 1.38) 1.14 (1.05, 1.24)****1.15 (1.06, 1.26)**
LanguagePET          0.38 (0.18, 0.81)**0.44 (0.21, 0.95)      
CSF          0.71 (0.39, 1.27)  0.71 (0.39, 1.29)      
ExecutivePET     1.02 (0.72, 1.45)  1.02 (0.72, 1.44) 0.68 (0.45, 1.04)  0.70 (0.46, 1.05) 0.95 (0.82, 1.11)  0.96 (0.82, 1.11) 
CSF     1.05 (0.76, 1.44)  1.05 (0.76, 1.44) 0.82 (0.55, 1.22)  0.83 (0.55, 1.24) 0.88 (0.76, 1.03)  0.89 (0.76, 1.04) 
VisuospatialPET1.36 (1.22, 1.52)******1.33 (1.19, 1.48)***0.92 (0.59, 1.45)  0.89 (0.56, 1.41)      1.30 (1.15, 1.49)******1.25 (1.10, 1.43)**
CSF1.38 (1.23, 1.55)******1.34 (1.19, 1.50)***1.34 (0.93, 1.93)  1.35 (0.95, 1.93)      1.21 (1.07, 1.37)****1.16 (1.03, 1.31)*
MRI MTAPET          0.77 (0.48, 1.24)  0.75 (0.47, 1.20)      
CSF          1.09 (0.69, 1.73)  0.98 (0.62, 1.54)      
MRI PCAPET          0.84 (0.47, 1.51)  0.85 (0.48, 1.51)      
CSF          0.74 (0.41, 1.32)  0.75 (0.42, 1.32)      
MRI FazekasPET     0.98 (0.53, 1.83)  0.92 (0.50, 1.71)           
CSF     1.38 (0.79, 2.41)  1.25 (0.72, 2.16)           
MRI
microbleeds
PET1.91 (1.21, 3.01)****1.59 (1.01, 2.50) 2.17 (0.75, 6.30)  1.84 (0.68, 4.99) 1.32 (0.52, 3.32)  1.11 (0.47, 2.62)      
CSF1.51 (0.96, 2.39)  1.35 (0.86, 2.10) 1.49 (0.52, 4.25)  1.32 (0.49, 3.52) 1.06 (0.42, 2.65)  0.98 (0.41, 2.32)      
  1. ***p < 0.001, **p < 0.01, *p < 0.05. p values indicate the significance of the patient feature in the model. Uncorrected p values and corrected p values are reported per model, additionally corrected p values for imputed data. False discovery rate (FDR) correction was performed for multiple comparisons. Cognitive scores have been multiplied by −1; therefore, lower scores usually indicate higher odds ratios for amyloid positivity