Total | SCD | MCI | Dementia | ||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Imputed | Imputed | Imputed | Imputed | ||||||||||||||||||
Predictor | Outcome | Odds ratio (95% CI) | punc | pFDR | Odds ratio (95% CI) | pFDR | Odds ratio (95% CI) | punc | pFDR | Odds ratio (95% CI) | pFDR | Odds ratio (95% CI) | punc | pFDR | Odds ratio (95% CI) | pFDR | Odds ratio (95% CI) | punc | pFDR | Odds ratio (95% CI) | pFDR |
Age | PET | 1.02 (1.00, 1.04) | 1.02 (1.00, 1.04) | 1.06 (1.01, 1.12) | * | 1.06 (1.01, 1.12) | 0.96 (0.92, 1.00) | 0.96 (0.92, 1.00) | |||||||||||||
CSF | 1.01 (0.99, 1.03) | 1.01 (0.99, 1.03) | 1.04 (1.00, 1.09) | 1.04 (1.00, 1.09) | 0.96 (0.92, 1.00) | 0.96 (0.92, 1.00) | |||||||||||||||
Sex, F | PET | 1.64 (0.81, 3.36) | 1.64 (0.81, 3.36) | 2.45 (1.14, 5.26) | * | 2.45 (1.14, 5.26) | 1.70 (1.13, 2.53) | ** | * | 1.70 (1.13, 2.53) | * | ||||||||||
CSF | 1.91 (0.99, 3.69) | 1.91 (0.99, 3.69) | 2.01 (0.94, 4.28) | 2.01 (0.94, 4.28) | 1.40 (0.93, 2.12) | 1.40 (0.93, 2.12) | |||||||||||||||
Education | PET | 1.06 (0.94, 1.19) | 1.07 (0.95, 1.20) | 1.28 (1.08, 1.52) | ** | ** | 1.30 (1.10, 1.53) | ** | |||||||||||||
CSF | 1.04 (0.93, 1.17) | 1.05 (0.94, 1.18) | 1.29 (1.08, 1.54) | ** | ** | 1.30 (1.09, 1.54) | ** | ||||||||||||||
APOE E4 | PET | 4.72 (3.46, 6.44) | *** | *** | 4.57 (3.34, 6.24) | *** | 2.97 (1.42, 6.20) | ** | * | 2.97 (1.42, 6.19) | * | 14.55 (6.08, 34.82) | *** | *** | 13.43 (5.62, 32.11) | *** | 3.63 (2.39, 5.50) | *** | *** | 3.51 (2.30, 5.34) | *** |
CSF | 4.60 (3.36, 6.28) | *** | *** | 4.46 (3.26, 6.12) | *** | 3.82 (1.90, 7.70) | *** | *** | 3.75 (1.86, 7.57) | ** | 8.28 (3.70, 18.54) | *** | *** | 7.76 (3.49, 17.27) | *** | 3.68 (2.39, 5.69) | *** | *** | 3.59 (2.33, 5.53) | *** | |
CSF tau | PET | 1.005 (1.004, 1.006) | *** | *** | 1.005 (1.004, 1.006) | *** | 1.004 (1.002, 1.006) | *** | *** | 1.004 (1.002, 1.006) | *** | 1.008 (1.005, 1.011) | *** | *** | 1.008 (1.005, 1.011) | *** | 1.004 (1.003, 1.005) | *** | *** | 1.004 (1.003, 1.005) | *** |
CSF | 1.004 (1.003, 1.005) | *** | *** | 1.004 (1.003, 1.005) | *** | 1.003 (1.002, 1.005) | *** | *** | 1.003 (1.002, 1.005) | ** | 1.003 (1.002, 1.005) | *** | *** | 1.003 (1.002, 1.005) | *** | 1.004 (1.003, 1.004) | *** | *** | 1.003 (1.002, 1.004) | *** | |
CSF p-tau | PET | 1.05 (1.04, 1.06) | *** | *** | 1.05 (1.04, 1.06) | *** | 1.04 (1.02, 1.05) | *** | *** | 1.04 (1.02, 1.05) | *** | 1.05 (1.03, 1.07) | *** | *** | 1.05 (1.03, 1.07) | *** | 1.05 (1.04, 1.06) | *** | *** | 1.05 (1.04, 1.06) | *** |
CSF | 1.04 (1.03, 1.04) | *** | *** | 1.04 (1.03, 1.04) | *** | 1.03 (1.01, 1.04) | *** | *** | 1.02 (1.01, 1.04) | ** | 1.03 (1.01, 1.04) | *** | *** | 1.03 (1.01, 1.04) | *** | 1.04 (1.03, 1.05) | *** | *** | 1.04 (1.03, 1.05) | *** | |
MMSE | PET | 1.20 (1.15, 1.25) | *** | *** | 1.19 (1.14, 1.24) | *** | 1.03 (0.89, 1.19) | 1.02 (0.88, 1.18) | |||||||||||||
CSF | 1.20 (1.15, 1.25) | *** | *** | 1.19 (1.14, 1.25) | *** | 1.15 (1.01, 1.31) | * | 1.13 (1.00, 1.29) | |||||||||||||
Memory | PET | 1.36 (1.27, 1.47) | *** | *** | 1.36 (1.27, 1.46) | *** | 1.13 (0.82, 1.55) | 1.14 (0.83, 1.56) | 1.26 (1.02, 1.57) | * | 1.25 (1.00, 1.54) | 1.20 (1.10, 1.30) | *** | *** | 1.20 (1.10, 1.31) | *** | |||||
CSF | 1.32 (1.23, 1.42) | *** | *** | 1.32 (1.23, 1.42) | *** | 1.23 (0.92, 1.64) | 1.22 (0.91, 1.62) | 1.16 (0.95, 1.42) | 1.12 (0.92, 1.38) | 1.14 (1.05, 1.24) | ** | ** | 1.15 (1.06, 1.26) | ** | |||||||
Language | PET | 0.38 (0.18, 0.81) | * | * | 0.44 (0.21, 0.95) | ||||||||||||||||
CSF | 0.71 (0.39, 1.27) | 0.71 (0.39, 1.29) | |||||||||||||||||||
Executive | PET | 1.02 (0.72, 1.45) | 1.02 (0.72, 1.44) | 0.68 (0.45, 1.04) | 0.70 (0.46, 1.05) | 0.95 (0.82, 1.11) | 0.96 (0.82, 1.11) | ||||||||||||||
CSF | 1.05 (0.76, 1.44) | 1.05 (0.76, 1.44) | 0.82 (0.55, 1.22) | 0.83 (0.55, 1.24) | 0.88 (0.76, 1.03) | 0.89 (0.76, 1.04) | |||||||||||||||
Visuospatial | PET | 1.36 (1.22, 1.52) | *** | *** | 1.33 (1.19, 1.48) | *** | 0.92 (0.59, 1.45) | 0.89 (0.56, 1.41) | 1.30 (1.15, 1.49) | *** | *** | 1.25 (1.10, 1.43) | ** | ||||||||
CSF | 1.38 (1.23, 1.55) | *** | *** | 1.34 (1.19, 1.50) | *** | 1.34 (0.93, 1.93) | 1.35 (0.95, 1.93) | 1.21 (1.07, 1.37) | ** | ** | 1.16 (1.03, 1.31) | * | |||||||||
MRI MTA | PET | 0.77 (0.48, 1.24) | 0.75 (0.47, 1.20) | ||||||||||||||||||
CSF | 1.09 (0.69, 1.73) | 0.98 (0.62, 1.54) | |||||||||||||||||||
MRI PCA | PET | 0.84 (0.47, 1.51) | 0.85 (0.48, 1.51) | ||||||||||||||||||
CSF | 0.74 (0.41, 1.32) | 0.75 (0.42, 1.32) | |||||||||||||||||||
MRI Fazekas | PET | 0.98 (0.53, 1.83) | 0.92 (0.50, 1.71) | ||||||||||||||||||
CSF | 1.38 (0.79, 2.41) | 1.25 (0.72, 2.16) | |||||||||||||||||||
MRI microbleeds | PET | 1.91 (1.21, 3.01) | ** | ** | 1.59 (1.01, 2.50) | 2.17 (0.75, 6.30) | 1.84 (0.68, 4.99) | 1.32 (0.52, 3.32) | 1.11 (0.47, 2.62) | ||||||||||||
CSF | 1.51 (0.96, 2.39) | 1.35 (0.86, 2.10) | 1.49 (0.52, 4.25) | 1.32 (0.49, 3.52) | 1.06 (0.42, 2.65) | 0.98 (0.41, 2.32) |