|
Patients with ≥ 1 ARIA-E event
|
MR-DBP (n = 13)
|
MR-DBA (n = 8)
|
SR (n = 7)
|
Total (n = 28)
|
MR-DBP (n = 6)
|
MR-DBA (n = 3)
|
SR (n = 4)
|
Total (n = 13)
|
|
Centiloid composite ROI—mean cerebellum gray
|
|
Baseline value, mean (SD)
|
90.47 (31.67)
|
68.01 (48.78)
|
67.19 (38.31)
|
78.23 (39.03)
|
82.35 (33.94)
|
63.94 (41.02)
|
78.83 (40.21)
|
77.02 (34.97)
|
|
Value at visit, mean (SD)
|
51.38 (23.42)
|
11.16 (38.04)
|
22.21 (28.82)
|
32.60 (33.73)
|
18.22 (21.77)
|
11.77 (50.63)
|
5.18 (24.58)
|
12.72 (28.46)
|
|
Change from baseline, mean (SD)
|
− 39.09 (30.90)
|
− 56.85 (29.52)
|
− 44.98 (33.43)
|
− 45.64 (30.93)
|
− 64.13 (20.28)
|
− 52.17 (28.66)
|
− 73.65 (33.89)
|
− 64.30 (25.72)
|
|
OLE week 52 change from baseline, mean (SD)
|
NA
|
NA
|
NA
|
NA
|
− 32.53 (31.50)
|
− 47.26 (12.93)
|
− 55.24 (40.53)
|
− 42.91 (31.01)
|
|
Patients without an ARIA-E event
|
MR-DBP (n = 14)
|
MR-DBA (n = 13)
|
SR (n = 12)
|
Total (n = 39)
|
MR-DBP (n = 10)
|
MR-DBA (n = 8)
|
SR (n = 8)
|
Total (n = 26)
|
|
Centiloid composite ROI—mean cerebellum gray
|
|
Baseline value, mean (SD)
|
91.65 (58.77)
|
86.65 (53.87)
|
39.39 (58.71)
|
73.90 (60.36)
|
97.15 (68.72)
|
81.59 (66.35)
|
65.02 (42.53)
|
82.47 (60.19)
|
|
Value at visit, mean (SD)
|
46.93 (45.38)
|
44.30 (45.29)
|
32.95 (42.31)
|
41.75 (43.67)
|
25.34 (31.63)
|
18.53 (40.38)
|
34.64 (34.31)
|
26.10 (34.47)
|
|
Change from baseline, mean (SD)
|
− 44.72 (38.26)
|
− 42.35 (21.23)
|
− 6.45 (53.14)
|
− 32.15 (41.99)
|
− 71.81 (48.25)
|
− 63.06 (32.84)
|
− 30.38 (17.33)
|
− 56.37 (39.37)
|
|
OLE week 52 change from baseline, mean (SD)b
|
NA
|
NA
|
NA
|
NA
|
− 41.80 (38.85)
|
− 46.72 (20.26)
|
− 18.68 (16.79)
|
− 36.90 (29.92)
|
