Table 1 OLE baseline characteristics of patients with PET scan at OLE week 52
Characteristic | MR-DBP (n = 27) | MR-DBA (n = 21) | SR (n = 19) |
|---|---|---|---|
Age at start of OLE, median (IQR), years | 74 (69–77) | 65 (59–79) | 72 (70–78) |
Female, n (%) | 12 (44) | 11 (52) | 11 (58) |
White, n (%) | 27 (100) | 20 (95) | 19 (100) |
APOEε4 genotype, n (%) | |||
0 | 9 (33) | 10 (48) | 2 (11) |
1 | 13 (48) | 4 (19) | 14 (74) |
2 | 5 (19) | 7 (33) | 3 (16) |
MMSE score at OLE baseline, mean (SD) | 21.6 (4.5) | 19.3 (5.0) | 18.8 (4.8) |
Centiloid at OLE baseline, mean (SD) | 91.1 (46.8) | 79.6 (51.6) | 49.6 (52.8) |
Duration on high dose, median (IQR), weeksa | 35 (33–37) | 42 (40–45) | 25 (21–33) |
Duration between baseline and week 52 PET scan, median (IQR), weeks | 68 (60–82) | 73 (64–88) | 55 (54–58) |
Patients with baseline PET scan below amyloid-β threshold, n (%) | 0 | 3 (14) | 7 (37) |