Table 2 Diagnostic performance of individual and combined models in detecting Aβ-PET positivity at Youden’s cutoff
Sensitivity | Specificity | PPV | NPV | LR+ | LR− | |
|---|---|---|---|---|---|---|
Whole population (N = 59) | ||||||
TP42/40 | 0.778 | 0.875 | 0.732 | 0.900 | 6.22 | 0.25 |
Age+APOE4+Clinical Group | 0.944 | 0.805 | 0.680 | 0.945 | 4.84 | 0.07 |
TP42/40+Age+APOE4+Clinical Group | 0.944 | 0.925 | 0.847 | 0.974 | 12.59 | 0.06 |
AD-Conv score | 1.000 | 0.675 | 0.706 | 1.000 | 3.08 | 0.00 |
AdjustedTP42/40+AD-Conv score | 1.000 | 0.923 | 0.851 | 1.000 | 13.00 | 0.00 |
Only CN (N = 39) | ||||||
TP42/40 | 1.000 | 0.886 | 0.500 | 1.000 | 8.75 | 0.00 |
Age+APOE4 | 0.750 | 0.943 | 0.600 | 0.971 | 12.12 | 0.26 |
TP42/40+Age+APOE4 | 1.000 | 1.000 | 1.000 | 1.000 | – | 0.00 |
AD-Conv score | 1.000 | 0.765 | 0.327 | 1.000 | 4.25 | 0.00 |
AdjustedTP42/40+AD-Conv score | 1.000 | 1.000 | 1.000 | 1.000 | – | 0.00 |
Only a-MCI (N = 20) | ||||||
TP42/40 | 0.714 | 1.000 | 1.000 | 0.653 | – | 0.29 |
Age+APOE4 | 0.357 | 0.833 | 0.799 | 0.411 | 2.14 | 0.77 |
TP42/40+Age+APOE4 | 0.643 | 1.000 | 1.000 | 0.601 | – | 0.36 |
AD-Conv score | 0.846 | 0.500 | 0.759 | 0.636 | 1.70 | 0.31 |
AdjustedTP42/40+AD-Conv score | 0.615 | 1.000 | 1.000 | 0.583 | – | 0.38 |