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Table 2 Association of baseline CSF Aβ peptide levels with cognition over time in DLB

From: Amyloid-β peptides in cerebrospinal fluid of patients with dementia with Lewy bodies

  MMSE score at baseline Change in MMSE over time
Predictors β (SE) p β (SE) p
Aβ42 1.02 (0.45) 0.027* 0.01 (0.19) 0.929
Aβ40 1.11 (0.43) 0.012* − 0.13 (0.22) 0.551
Aβ38 1.03 (0.43) 0.020* − 0.11 (0.22) 0.618
Aβ42/Aβ40 ratio 0.29 (0.49) 0.556 0.19 (0.20) 0.340
Aβ42/Aβ38 ratio 0.25 (0.48) 0.594 0.18 (0.20) 0.383
Aβ38/Aβ40 ratio 0.43 (0.44) 0.331 0.00 (0.23) 0.976
  1. Data are presented as standardized estimates (β) with their standard error (SE) and p value. Linear mixed models were used with terms for time (years), CSF Aβ peptide measures, and an interaction term of CSF Aβ peptide measure × time as independent variables and MMSE score as the dependent variable. For all models, a random intercept and slope were assumed. Aβ peptide levels were transformed to z-scores. A beta coefficient of one (β = 1) therefore implies that a 1 standard deviation increase in CSF Aβ peptide was associated with a 1-point increase in MMSE score. The models (one model per CSF Aβ peptide) were adjusted for age, sex, and education
  2. Abbreviations: Aβ42 amyloid β1-42 determined with MSD ELISA assay, Aβ40 amyloid β1-40 determined with MSD ELISA assay, Aβ38 amyloid β1-38 determined with MSD ELISA assay
  3. *p < 0.05