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Table 2 Baseline demographic and clinical characteristics

From: Discordant amyloid-β PET and CSF biomarkers and its clinical consequences

CSF/PET profile Total (N = 768) SCD (N = 194) MCI (N = 127) AD dementia (N = 309) Non-AD dementia (N = 138)
−/− Disc. +/+ −/− Disc. +/+ −/− Disc. +/+ −/− Disc. +/+ −/− Disc. +/+
N (%) 315 (41) 97 (13) 356 (46) 136 (70) 30 (15) 28 (14) 55 (43) 17 (13) 55 (43) 28 (9) 28 (9) 253 (82) 96 (70) 22 (16) 20 (14)
Age (SD) 63 (8) 63 (9) 64 (7) 60 (7) 60 (7) 61 (9) 67 (7) 66 (9) 64 (8) 65 (7) 65 (8) 63 (7) 64 (8) 63 (9) 67 (5)
Sex, male (%) 211 (67) 58 (60) 192 (54) 85 (63) 20 (67) 11 (39) 43 (78) 10 (59) 32 (58) 20 (71) 13 (46) 136 (54) 63 (66) 15 (68) 13 (65)
Education (IQR) 5 (4–6) 5 (4–6) 5 (4–6) 6 (5–6) 5 (4–6) 6 (5–7) 6 (5–6) 6 (5–6) 5 (5–6) 5 (4–6) 5 (4–6) 5 (4–6) 5 (4–5) 5 (4–5) 6 (5–6)
MMSE (SD) 26 (3)c 24 (4) 23 (4)b 28 (2) 27 (3) 28 (3) 27 (2) 26 (3) 27 (2) 24 (3) 22 (4) 22 (4) 24 (4) 23 (5) 24 (4)
Cognitive domains (Z-scores):
 Memory (SD) −1.4 (2.3)c −2.5 (2.9) −3.3 (2.8)a − 0.3 (0.9)a −0.9 (1.7) −0.3 (1.0) −1.6 (2.0) −2.1 (1.8) −2.3 (1.8) −3.4 (2.3) −4.0 (3.5) −4.0 (2.8) −2.3 (2.9) −3.0 (3.1) −2.3 (2.1)
 Language (SD) −0.7 (1.3)b −1.3 (2.1) −1.0 (1.8) −0.1 (0.8) −0.2 (0.5) 0.0 (0.5) −0.5 (0.7) −0.8 (0.8) −0.2 (0.4)b −1.3 (1.3) −1.9 (2.2) −1.3 (1.9) −1.4 (1.7) −2.3 (3.0) −2.0 (2.9)
 Attention (SD) −0.7 (1.1) −0.9 (1.0) −1.1 (1.2) −0.2 (0.8) −0.5 (1.0) −0.2 (1.3) −0.5 (0.8) −0.6 (1.0) −0.3 (0.7) −1.2 (1.1) −1.3 (0.9) −1.4 (1.2) −1.4 (1.2) −1.4 (1.0) −1.4 (1.0)
 Executive (SD) −1.0 (1.4) −1.3 (1.4) −1.5 (1.4) −0.2 (1.0) −0.5 (1.3) −0.1 (1.0) −0.8 (0.9) −0.6 (0.9) −0.5 (0.9) −1.9 (1.1) −2.1 (1.1) −1.9 (1.3) −2.1 (1.3) −1.9 (1.4) −1.9 (1.3)
 Visuospatial (SD) −0.3 (1.2)a −0.9 (1.8) −1.4 (2.4) 0.0 (0.6) −0.4 (1.8) 0.0 (1.0) −0.3 (1.0) −0.7 (1.1) −0.1 (1.0) −0.8 (1.3) −1.4 (2.1) −1.8 (2.6) −0.8 (1.6) −1.2 (1.5) −1.2 (1.4)
  1. Abbreviations: AD Alzheimer’s disease, CSF cerebrospinal fluid, IQR interquartile range, MCI mild cognitive impairment, PET positron emission tomography, SCD subjective cognitive decline, SD standard deviation
  2. Data are presented as No. (%), mean (SD) or median (IQR). Within diagnostic groups, we calculated differences between discordant and both concordant groups
  3. Education was unavailable for 28 (4%) patients, APOE genotype for 32 (4%), and MMSE for 15 (2%). Based on missing data, we could not construct a Z-score for n (%) patients for the following domains: 41 (5%) for memory, 48 (6%) for language, 43 (6%) for attention, 21 (3%) for executive functioning, and 67 (9%) for visuospatial functioning
  4. aP < 0.05
  5. bP < 0.01
  6. cP < 0.001