Table 2 Baseline demographic and clinical characteristics
From: Discordant amyloid-β PET and CSF biomarkers and its clinical consequences
CSF/PET profile | Total (N = 768) | SCD (N = 194) | MCI (N = 127) | AD dementia (N = 309) | Non-AD dementia (N = 138) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
−/− | Disc. | +/+ | −/− | Disc. | +/+ | −/− | Disc. | +/+ | −/− | Disc. | +/+ | −/− | Disc. | +/+ | |
N (%) | 315 (41) | 97 (13) | 356 (46) | 136 (70) | 30 (15) | 28 (14) | 55 (43) | 17 (13) | 55 (43) | 28 (9) | 28 (9) | 253 (82) | 96 (70) | 22 (16) | 20 (14) |
Age (SD) | 63 (8) | 63 (9) | 64 (7) | 60 (7) | 60 (7) | 61 (9) | 67 (7) | 66 (9) | 64 (8) | 65 (7) | 65 (8) | 63 (7) | 64 (8) | 63 (9) | 67 (5) |
Sex, male (%) | 211 (67) | 58 (60) | 192 (54) | 85 (63) | 20 (67) | 11 (39) | 43 (78) | 10 (59) | 32 (58) | 20 (71) | 13 (46) | 136 (54) | 63 (66) | 15 (68) | 13 (65) |
Education (IQR) | 5 (4–6) | 5 (4–6) | 5 (4–6) | 6 (5–6) | 5 (4–6) | 6 (5–7) | 6 (5–6) | 6 (5–6) | 5 (5–6) | 5 (4–6) | 5 (4–6) | 5 (4–6) | 5 (4–5) | 5 (4–5) | 6 (5–6) |
MMSE (SD) | 26 (3)c | 24 (4) | 23 (4)b | 28 (2) | 27 (3) | 28 (3) | 27 (2) | 26 (3) | 27 (2) | 24 (3) | 22 (4) | 22 (4) | 24 (4) | 23 (5) | 24 (4) |
Cognitive domains (Z-scores): | |||||||||||||||
Memory (SD) | −1.4 (2.3)c | −2.5 (2.9) | −3.3 (2.8)a | − 0.3 (0.9)a | −0.9 (1.7) | −0.3 (1.0) | −1.6 (2.0) | −2.1 (1.8) | −2.3 (1.8) | −3.4 (2.3) | −4.0 (3.5) | −4.0 (2.8) | −2.3 (2.9) | −3.0 (3.1) | −2.3 (2.1) |
Language (SD) | −0.7 (1.3)b | −1.3 (2.1) | −1.0 (1.8) | −0.1 (0.8) | −0.2 (0.5) | 0.0 (0.5) | −0.5 (0.7) | −0.8 (0.8) | −0.2 (0.4)b | −1.3 (1.3) | −1.9 (2.2) | −1.3 (1.9) | −1.4 (1.7) | −2.3 (3.0) | −2.0 (2.9) |
Attention (SD) | −0.7 (1.1) | −0.9 (1.0) | −1.1 (1.2) | −0.2 (0.8) | −0.5 (1.0) | −0.2 (1.3) | −0.5 (0.8) | −0.6 (1.0) | −0.3 (0.7) | −1.2 (1.1) | −1.3 (0.9) | −1.4 (1.2) | −1.4 (1.2) | −1.4 (1.0) | −1.4 (1.0) |
Executive (SD) | −1.0 (1.4) | −1.3 (1.4) | −1.5 (1.4) | −0.2 (1.0) | −0.5 (1.3) | −0.1 (1.0) | −0.8 (0.9) | −0.6 (0.9) | −0.5 (0.9) | −1.9 (1.1) | −2.1 (1.1) | −1.9 (1.3) | −2.1 (1.3) | −1.9 (1.4) | −1.9 (1.3) |
Visuospatial (SD) | −0.3 (1.2)a | −0.9 (1.8) | −1.4 (2.4) | 0.0 (0.6) | −0.4 (1.8) | 0.0 (1.0) | −0.3 (1.0) | −0.7 (1.1) | −0.1 (1.0) | −0.8 (1.3) | −1.4 (2.1) | −1.8 (2.6) | −0.8 (1.6) | −1.2 (1.5) | −1.2 (1.4) |