Number
|
25
|
23
|
70
| | |
Sex (m/f)
|
11/14
|
14/9
|
29/41
|
0.26a
| |
Age
|
67.0 (±7.1)
|
64.5 (±6.8)
|
66.3 (±7.7)
|
0.47b
| |
MMSE
|
22.1 (±5.4)
|
19.8 (±5.6)
|
29.5 (±0.8)
|
< 0.001
c
| |
Biomarkers
|
Posterior cortical atrophy
|
Typical Alzheimer’s disease
|
Controls
|
Linear regression modelsc
|
PCA
|
tAD
|
Beta
|
p value
|
Beta
|
p value
|
OCT1
|
Mean peripapillary retinal nerve fibre layer thickness (pRNFL) (μm)
|
98.8 (±12.2)
|
99.9 (±8.7)
|
99.6 (±10.0)
|
− 0.02
|
0.80
|
− 0.01
|
0.89
|
Mean macular retinal thickness (mRT) (μm)
|
266.9 (±16.3)
|
267.8 (±13.6)
|
269.3 (±13.6)
|
− 0.07
|
0.50
|
− 0.09
|
0.38
|
MRI subset2
|
AD Signature Thickness (mm)
|
2.5 (±0.2)
|
2.5 (±0.2)
|
2.8 (±0.1)
|
− 0.73
|
< 0.001
|
− 0.60
|
< 0.001
|
Hippocampus volume (mm3)
|
6631.4 (±713.9)
|
6411.6 (±1072.1)
|
7847.8 (±873.5)
|
− 0.44
|
< 0.001
|
−0.61
|
< 0.001
|
PCA signature thickness (mm)
|
1.7 (±0.2)
|
1.9 (±0.1)
|
2.1 (±0.1)
|
− 0.78
|
< 0.001
|
− 0.35
|
< 0.001
|
Estimated intracranial volume (*106 mm3)
|
1.5 (±0.1)
|
1.5 (±0.2)
|
1.5 (±0.2)
|
−0.14
|
0.21
|
−0.15
|
0.17
|
CSF subset3
|
Aβ-1-42 (ng/L)
|
395.9 (±140.1)
|
300.1 (±133.2)
|
900.9 (±221.9)
|
− 0.70
|
< 0.001
|
− 0.90
|
< 0.001
|
Tau−181 (ng/L)
|
573.4 (±306.4)
|
778.2 (±359.1)
|
265.1 (±119.2)
|
0.32
|
0.07
|
0.65
|
< 0.001
|
Tau−181/Aβ1–42 ratio
|
1.6 (±1.0)
|
3.1 (±1.8)
|
0.3 (±0.1)
|
0.22
|
0.18
|
0.68
|
< 0.001
|