Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

Miebach, Lisa; Wolfsgruber, Steffen; Polcher, Alexandra; Peters, Oliver; Menne, Felix; Luther, Katja; Incesoy, Enise; Priller, Josef; Spruth, Eike; Altenstein, Slawek; Buerger, Katharina; Catak, Cihan; Janowitz, Daniel; Perneczky, Robert; Utecht, Julia; Laske, Christoph; Buchmann, Martina; Schneider, Anja; Fliessbach, Klaus; Kalbhen, Pascal; Heneka, Michael T.; Brosseron, Frederic; Spottke, Annika; Roy, Nina; Teipel, Stefan J.; Kilimann, Ingo; Wiltfang, Jens; Bartels, Claudia; Düzel, Emrah; Dobisch, Laura; Metzger, Coraline; Meiberth, Dix; Ramirez, Alfredo; Jessen, Frank; Wagner, Michael

doi:10.1186/s13195-019-0515-y

Alzheimer's Research & Therapy

Table 4 Linear regression with the number of fulfilled SCD-plus features and the number of reported SCD domains predicting AD biomarkers

From: Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

Predictor variables	Dependent variables
	CSF Aß-42-level (pg/ml)			CSF Aß-42/tau-ratio			CSF-p-tau-181 (pg/ml)			CSF total Tau (pg/ml)
	B	SE (B)	ß	B	SE (B)	ß	B	SE (B)	ß	B	SE (B)	ß
Unadjusted model
SCD-plus features	R² = .054, F for change in R² = 11.49***			R² = .047, F for change in R² = 10.024***			R² = .006. F for change in R² = 1.139			R² = .001. F for change in R² = .001
SCD-plus features	− 0.059	0.017	− 0.233***	− 0.056	0.019	− 0.217**	− .006	0.016	− 0.028	2.798E−05	0.018	0.000
SCD-I domains	R² = .044, F for change in R² = 9.213**			R² = .029, F for change in R² = 6.015*			R² = .006, F for change in R² = 1.139			R² = .003. F for change in R² = .610
SCD-I domains	− .062	0.020	− 0.209**	− 0.056	0.023	− 0.170*	− 0.020	0.019	− 0.077	− .016	.020	− .055
Covariate-adjusted model (age, sex, education)
SCD-plus features	R² = .076, F for change in R² = 1.57			R² = .110, F for change in R² = 4.679**			R² = .067, F for change in R² = 4.488**			R² = .091. F for change in R² = 6.548***
SCD-plus features	− 0.057	0.018	− 0.225***	− 0.053	0.022	− 0.189**	− .016	0.016	− 0.074	− 0.011	0.017	− 0.043
SCD-I domains	R² = .067, F for change in R² = 1.64			R² = .096, F for change in R² = 4.953**			R² = .075, F for change in R² = 4.731**			R² = .097. F for change in R² = 6.816***
SCD-I domains	− 0.060	0.020	− 0.203**	− 0.048	0.022	− 0.146*	− 0.030	0.018	− 0.118	− 0.026	0.020	− 0.090
Covariate-adjusted model (age, sex, education, and delayed recall)
SCD-plus features	R² = .109, F for change in R² = 7.35**			R² = .135, F for change in R² = 5.657*			R² = .088, F for change in R² = 4.298*			R² = .115. F for change in R² = 5.430*
SCD-plus features	− 0.053	0.017	− 0.210**	− 0.050	0.019	− 0.177**	− 1.037	0.863	− 0.083	− 0.014	0.017	− 0.056
Delayed recall	0.048	0.018	0.194**	0.046	0.019	0.167*	− 1.964	.895	− 0.152*	− 0.041	0.017	− 0.166*
Delayed recall	R² = .103, F for change in R² = 7.908**			R² = .123, F for change in R² = 6.040*			R² = .095, F for change in R² = 4.257*			R² = .122. F for change in R² = 5.524*
SCD-I domains	− 0.057	0.020	− 0.193**	− 0.045	0.022	− 0.138*	− 0.031	0.018	− 0.122	− 0.028	0.020	− 0.098
Delayed recall	0.050	0.018	0.201**	0.048	0.020	0.174*	− 0.033	0.016	− 0.151*	− 0.041	0.017	− 0.167*

Full models are shown in the Additional file 1: Table S1 and Table S2
SE standard error, B unstandardized beta, ß standardized beta
*p < .05; **p < .01; ***p < .001

Back to article page

ISSN: 1758-9193

Contact us

General enquiries: journalsubmissions@springernature.com