Skip to main content

Advertisement

Table 4 Linear regression with the number of fulfilled SCD-plus features and the number of reported SCD domains predicting AD biomarkers

From: Which features of subjective cognitive decline are related to amyloid pathology? Findings from the DELCODE study

Predictor variables Dependent variables  
CSF Aß-42-level (pg/ml) CSF Aß-42/tau-ratio CSF-p-tau-181 (pg/ml) CSF total Tau (pg/ml)
B SE (B) ß B SE (B) ß B SE (B) ß B SE (B) ß
Unadjusted model  
 SCD-plus features R2 = .054, F for change in R2 = 11.49*** R2 = .047, F for change in R2 = 10.024*** R2 = .006. F for change in R2 = 1.139 R2 = .001. F for change in R2 = .001
− 0.059 0.017 − 0.233*** − 0.056 0.019 − 0.217** − .006 0.016 − 0.028 2.798E−05 0.018 0.000
 SCD-I domains R2 = .044, F for change in R2 = 9.213** R2 = .029, F for change in R2 = 6.015* R2 = .006, F for change in R2 = 1.139 R2 = .003. F for change in R2 = .610
− .062 0.020 − 0.209** − 0.056 0.023 − 0.170* − 0.020 0.019 − 0.077 − .016 .020 − .055
Covariate-adjusted model (age, sex, education)  
 SCD-plus features R2 = .076, F for change in R2 = 1.57 R2 = .110, F for change in R2 = 4.679** R2 = .067, F for change in R2 = 4.488** R2 = .091. F for change in R2 = 6.548***
− 0.057 0.018 − 0.225*** − 0.053 0.022 − 0.189** − .016 0.016 − 0.074 − 0.011 0.017 − 0.043
 SCD-I domains R2 = .067, F for change in R2 = 1.64 R2 = .096, F for change in R2 = 4.953** R2 = .075, F for change in R2 = 4.731** R2 = .097. F for change in R2 = 6.816***
− 0.060 0.020 − 0.203** − 0.048 0.022 − 0.146* − 0.030 0.018 − 0.118 − 0.026 0.020 − 0.090
Covariate-adjusted model (age, sex, education, and delayed recall)   
 SCD-plus features R2 = .109, F for change in R2 = 7.35** R2 = .135, F for change in R2 = 5.657* R2 = .088, F for change in R2 = 4.298* R2 = .115. F for change in R2 = 5.430*
− 0.053 0.017 − 0.210** − 0.050 0.019 − 0.177** − 1.037 0.863 − 0.083 − 0.014 0.017 − 0.056
 Delayed recall 0.048 0.018 0.194** 0.046 0.019 0.167* − 1.964 .895 − 0.152* − 0.041 0.017 − 0.166*
R2 = .103, F for change in R2 = 7.908** R2 = .123, F for change in R2 = 6.040* R2 = .095, F for change in R2 = 4.257* R2 = .122. F for change in R2 = 5.524*
 SCD-I domains − 0.057 0.020 − 0.193** − 0.045 0.022 − 0.138* − 0.031 0.018 − 0.122 − 0.028 0.020 − 0.098
 Delayed recall 0.050 0.018 0.201** 0.048 0.020 0.174* − 0.033 0.016 − 0.151* − 0.041 0.017 − 0.167*
  1. Full models are shown in the Additional file 1: Table S1 and Table S2
  2. SE standard error, B unstandardized beta, ß standardized beta
  3. *p < .05; **p < .01; ***p < .001