Fig. 5

Deficiency in odor discrimination and LC degeneration in 17–20-month-old rats infused with htauE14 at 12–14 months old. a Schematics of the time course of the AAV infusion, odor discrimination training, and histology. b Simple odor discrimination (SOD) training using dissimilar odors. (N: htau/GFP: 4/7). c–e LC cell counts in htauE14 and control rats. (N: htau/GFP: 6/5). f–h NET fibers (red) in the piriform cortex (PC). (N: htau/GFP: 6/6). i–k DBH fibers (red) in the PC. (N: htau/GFP: 6/6). l–n Iba-1 staining in the PC. (N: htau/GFP: 6/6). Scale bars, 50 μm