Skip to main content

Advertisement

Table 1 Effect of rHDL-rApoJ nanodiscs or free rApoJ on brain inflammatory status, analyzed by multiplexed ELISA. Data are expressed as the mean ± SEM. N = 5–7/group. *p < 0.05 and **p < 0.01 refer to statistical differences vs. the saline-treated group determined by one-way ANOVA test (plus multiple comparison test). The false discovery rate (FDR) correction was used to control for multiple testing in the multiplexed analysis of brain inflammatory status

From: Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

Inflammatory markers APP23 saline (pg/mg) APP23 rHDL-rApoJ (pg/mg) APP23 free rApoJ (pg/mg) One-way ANOVA (3 groups) p value rHDL-rApoJ vs saline FDR-corrected p value Free rApoJ vs saline FDR-corrected p value
FGF-basic 984.4 ± 154.6 895.6 ± 113.3 560.2 ± 151.4 p = 0.108 p = 0.787 p = 0.174
IL-1β 85.28 ± 12.17 50.86 ± 3.75 72.91 ± 11.43 p = 0.080 p = 0.122 p = 0.448
IL2 151.0 ± 13.09 116.7 ± 14.22 125.2 ± 14.49 p = 0.222 p = 0.198 p = 0.324
IL5 141.7 ± 26.35 130.61 ± 27.54 148.0 ± 21.31 p = 0.893 p = 0.819 p = 0.874
IL6 203.1 ± 22.15 177.7 ± 28.82 176.3 ± 19.5 p = 0.656 p = 0.583 p = 0.448
IL13 21.31 ± 3.40 17.68 ± 2.34 12.63 ± 3.22 p = 0.171 p = 0.552 p = 0.183
IL17 20.01 ± 2.33 13.9 ± 1.37* 10.23 ± 1.08** p = 0.004 p = 0.122 p = 0.017
IFN-γ 127.8 ± 15.53 89.81 ± 13.28 94.08 ± 10.68 p = 0.123 p = 0.137 p = 0.194
IP10 54.4 ± 4.34 44.48 ± 5.11 46.71 ± 5.05 p = 0.330 p = 0.289 p = 0.388
KC 1558 ± 115.5 1206 ± 112.0* 1043 ± 104.6** p = 0.012 p = 0.122 p = 0.029
MIG 81.65 ± 8.21 57.81 ± 6.91 61.48 ± 8.72 p = 0.090 p = 0.122 p = 0.194
TNF-α 127.2 ± 13.46 125.2 ± 9.43 144.7 ± 17.79 p = 0.620 p = 0.937 p = 0.448
VEGF 17.67 ± 2.36 14.27 ± 2.35 10.72 ± 1.22 p = 0.080 p = 0.399 p = 0.129
MCP-1 36.1 ± 3.93 24.31 ± 2.84 28.19 ± 3.12 p = 0.060 p = 0.122 p = 0.194