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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Peripheral administration of human recombinant ApoJ/clusterin modulates brain beta-amyloid levels in APP23 mice

Fig. 3

Cerebral Aβ levels in 15-month-old APP23 mice treated subchronically with saline, rHDL-rApoJ nanodiscs, or free rApoJ. a Cerebral soluble Aβ40 levels. b Cerebral insoluble Aβ40. c Cerebral insoluble Aβ42, detected by ELISA. d Representative images showing ThS-positive vessels and the corresponding quantification in brain sections. e Representative images showing ThS-positive deposits, quantification of the number of ThS-positive deposits per area (px2), and quantification of the mean size of those deposits. f Representative images of anti-Aβ (4G8)-positive deposits in the brain parenchyma, quantification of the number of Aβ-positive deposits per area (px2), and quantification of the mean size of those deposits. Data are expressed as the mean ± SEM. N = 7/group. *p < 0.05; **p < 0.01

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