Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13195-019-0498-8/MediaObjects/13195_2019_498_Fig1_HTML.png)
Levels of cerebral insoluble Aβ and mouse ApoJ expression in APP23 transgenic mice over time. a Cerebral accumulation of insoluble Aβ40 in 15- and 24-month-old APP23 and wt mice. b Cerebral accumulation of insoluble Aβ42 in 15- and 24-month-old APP23 and wt mice. c Mouse ApoJ (m-ApoJ) cerebral expression in 15- and 24-month-old APP23 and wt mice. d Mouse ApoJ (m-ApoJ) levels in the plasma of 15 and 24-month-old APP23 mice. Data are expressed as the mean ± SEM. N = 3–4/group. *p < 0.05; **p < 0.01; *p < 0.001