Fig. 1

Levels of cerebral insoluble Aβ and mouse ApoJ expression in APP23 transgenic mice over time. a Cerebral accumulation of insoluble Aβ₄₀ in 15- and 24-month-old APP23 and wt mice. b Cerebral accumulation of insoluble Aβ₄₂ in 15- and 24-month-old APP23 and wt mice. c Mouse ApoJ (m-ApoJ) cerebral expression in 15- and 24-month-old APP23 and wt mice. d Mouse ApoJ (m-ApoJ) levels in the plasma of 15 and 24-month-old APP23 mice. Data are expressed as the mean ± SEM. N = 3–4/group. *p < 0.05; **p < 0.01; *p < 0.001